2,3,5-三甲基苯酚合成路线 （共 124 条）
反应条件
peracetic acid T=50°C; 0.25 h; Product distributionKineticsThermodynamic data;
参考文献
Kharchuk, V. G.; Kolenko, I. P.; Petrov, L. A.; Gus'kova, L. M.
Journal of Organic Chemistry USSR (English Translation), 1986 , vol. 22, # 11 p. 2071 - 2078
Zhurnal Organicheskoi Khimii, 1986 , vol. 22, # 11 p. 2306 - 2315
反应条件
sulfuric acid T=50°C; 0.5 h; effect of catalysts; MechanismThermodynamic data;
参考文献
Kharchuk, V. G.; Kolenko, I. P.
J. Gen. Chem. USSR (Engl. Transl.), 1987 , vol. 57, # 4 p. 923 - 930,819 - 826
反应条件
sulfuric acid in toluene 4 h; Reflux;
参考文献
Garcia, Oscar; Bofill, Josep M.; Nicolas, Ernesto; Albericio, Fernando
European Journal of Organic Chemistry, 2010 , # 19 p. 3631 - 3640
反应条件
1: 44 percent / ZnCl2 / acetic acid / 1.) 23 deg C, 12 h 2.) 150 deg C, 7 h 2: 53 percent / chlorosulphonic acid / CHCl3 / 1.) -5 deg C, 15 min 2.) -5 deg C -> rt, 1 h View Scheme
参考文献
Ramage; Green; Blake
Tetrahedron, 1991 , vol. 47, # 32 p. 6353 - 6370
反应条件
pyridine in dichloromethane T=20°C;
参考文献
Sankyo Agro Company, Limited
Patent: EP1426365 A1, 2004 ;
Location in patent: Page 288 ;
反应条件
peracetic acid T=50°C; 0.25 h; Product distributionKineticsThermodynamic data;
参考文献
Kharchuk, V. G.; Kolenko, I. P.; Petrov, L. A.; Gus'kova, L. M.
Journal of Organic Chemistry USSR (English Translation), 1986 , vol. 22, # 11 p. 2071 - 2078
Zhurnal Organicheskoi Khimii, 1986 , vol. 22, # 11 p. 2306 - 2315
反应条件
sulfuric acid T=50°C; 0.5 h; effect of catalysts; MechanismThermodynamic data;
参考文献
Kharchuk, V. G.; Kolenko, I. P.
J. Gen. Chem. USSR (Engl. Transl.), 1987 , vol. 57, # 4 p. 923 - 930,819 - 826
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; Alkylation; 18 h;
参考文献
Edwards, Philip D.; Mauger, Russell C.; Cottrell, Kevin M.; Morris, Frank X.; Pine, Kara K.; Sylvester, Mark A.; Scott, Clay W.; Furlong, Stephen T.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 20 p. 2291 - 2294
反应条件
1: 44 percent / ZnCl2 / acetic acid / 1.) 23 deg C, 12 h 2.) 150 deg C, 7 h 2: 53 percent / chlorosulphonic acid / CHCl3 / 1.) -5 deg C, 15 min 2.) -5 deg C -> rt, 1 h 3: 3.2 M sodium hydroxide / acetone / 1.) 0 deg C, 2 h 2.) rt, 2 h 4: H2 / 10percent Pd/C / methanol 5: 89 percent / 6percent aq. sodium carbonate / dimethylformamide / 1 h View Scheme
参考文献
Tetrahedron, , vol. 47, # 32 p. 6353 - 6370
反应条件
trifluorormethanesulfonic acid in toluene T=110°C; 1 h;
参考文献
Yamashita, Makoto; Ono, Yujirou; Tawada, Hiroyuki
Tetrahedron, 2004 , vol. 60, # 12 p. 2843 - 2849
