1-羟基环己烷丙酸 gamma-内酯合成路线 （共 73 条）
反应条件
pyridine; xanthone powder; bis(2,4-acetylacetonate)cobalt(II); hydrogen in tetrahydrofuran
P=760 Torr; Ambient temperatureIrradiation;
参考文献
Chow, Yuan L.; Huang, Yu-Jin; Dragojlovic, Veljko
Canadian Journal of Chemistry, 1995 , vol. 73, # 5 p. 740 - 742
反应条件
Sm(III) chloride; tetra-n-butylammonium tetrafluoroborate; magnesium in N,N-dimethyl-formamide
T=20°C; electrosynthesis;
参考文献
Hebri, Hassan; Dunach, Elisabet; Perichon, Jacques
Journal of the Chemical Society, Chemical Communications, 1993 , # 6 p. 499 - 500
反应条件
NiI2; samarium diiodide in tetrahydrofuran
Addition; 1 h;
参考文献
Machrouhi, Fouzia; Namy, Jean-Louis
Tetrahedron, 1998 , vol. 54, # 37 p. 11111 - 11122
反应条件
1: With n-butyllithium; 4,4'-di-tert-butylbiphenyl; lithium in tetrahydrofuran
T=-78°C; Metallation; addition;
2: With water in tetrahydrofuran
T=-78 - 20°C; Hydrolysis;
3: With toluene-4-sulfonic acid in benzene
Cyclization; Heating;
参考文献
Pastor, Isidro M.; Yus, Miguel
Tetrahedron Letters, 2000 , vol. 41, # 28 p. 5335 - 5339
反应条件
sulfuric acid in water
T=100°C; 48 h;
参考文献
Patel, Nandini C.; Schwarz, Jacob B.; Islam, Khondaker; Miller, Whitney; Tran, Tuan P.; Wei, Yunjing
Synthetic Communications, 2011 , vol. 41, # 15 p. 2209 - 2215
反应条件
samarium diiodide; tert-butyl alcohol in tetrahydrofuran
2 h; Ambient temperature;
参考文献
Fukuzawa, Shin-ichi; Nakanishi, Akira; Fujinami, Tatsuo; Sakai, Shizuyoshi
Journal of the Chemical Society, Chemical Communications, 1986 , # 8 p. 624 - 625
反应条件
hydrogenchloride; Pd(MeCN)2Cl(NO2); copper dichloride in acetonitrile
16 h; Ambient temperature;
参考文献
Compain, Philippe; Gore, Jacques; Vatele, Jean-Michel
Tetrahedron, 1996 , vol. 52, # 31 p. 10405 - 10416
反应条件
[bis(acetoxy)iodo]benzene; iodine in dichloromethane
Irradiation;
参考文献
Martin, Angeles; Perez-Martin, Ines; Suarez, Ernesto
Organic Letters, 2005 , vol. 7, # 10 p. 2027 - 2030
反应条件
1: 94 percent / m-chloroperbenzoic acid / CH2Cl2
2: 78 percent / BF3*Et2O / methanol / 0 - 20 °C
3: 76 percent / Jones reagent / acetone / 0.17 h / 0 °C
View Scheme
参考文献
Ehlinger, Ed; Magnus, Philip
Journal of the American Chemical Society, 1980 , vol. 102, # 15 p. 5004 - 5011
反应条件
1: 78 percent / BF3*Et2O / methanol / 0 - 20 °C
2: 76 percent / Jones reagent / acetone / 0.17 h / 0 °C
View Scheme
参考文献
Ehlinger, Ed; Magnus, Philip
Journal of the American Chemical Society, 1980 , vol. 102, # 15 p. 5004 - 5011
