1-羟基环己烷丙酸 gamma-内酯合成路线 （共 73 条）
反应条件
di-tert-butyl peroxide
参考文献
Snowden, Roger L.; Brauchli, Robert; Linder, Simon
Helvetica Chimica Acta, 2011 , vol. 94, # 7 p. 1216 - 1225
反应条件
boron trifluoride diethyl etherate; water; naphthalenyllithium; 3-chloro-benzenecarboperoxoic acid
1.) THF, -78 deg C, 6 h, 2.) 20 deg C, 2 h, 3.) CH2Cl2; Yield given. Multistep reaction;
参考文献
Barluenga, Jose; Fernandez, Jose R.; Rubiera, Covadonga; Yus, Miguel
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 3113 - 3118
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; samarium diiodide in tetrahydrofuran
Ambient temperature;
参考文献
Csuk; Hu; Abdou; Kratky
Tetrahedron, 1991 , vol. 47, # 34 p. 7037 - 7044
反应条件
ethyl acetate; platinum
Hydrogenation;
参考文献
Mathieson
Journal of the Chemical Society, 1951 , p. 177,180
反应条件
1: 1.) tetrabutylammonium fluoride, water / 1.) THF, 15-30 min, 2.) CH2Cl2
2: triethylamine
View Scheme
参考文献
Davies, D. Huw; Hall, Jonathan; Smith, Edward H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 837 - 838
反应条件
sulfuric acid
1.) electrochemical reaction: mercury pool cathode, platinum anode, H2SO4, ethanol, H2O, 30 deg C, 2.) reflux, 5-6 h; Yield given. Multistep reaction;
参考文献
Prasad; Misra
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1990 , vol. 29, # 4 p. 392 - 393
参考文献
Kostas, Ioannis D.; Screttas, Constantinos G.
Journal of Organic Chemistry, 1997 , vol. 62, # 16 p. 5575 - 5577
反应条件
toluene-4-sulfonic acid in chloroform-d1
参考文献
Hofland, A.; Boer, Th. J.
Recueil des Travaux Chimiques des Pays-Bas, 1987 , vol. 106, # 11 p. 558 - 562
参考文献
Linstead; Millidge; Walpole
Journal of the Chemical Society, 1937 , p. 1140,1145
反应条件
1: 85 percent / LiBH4 / tetrahydrofuran / 36 h / Ambient temperature
2: 88 percent / tosyl chloride, anhydrous pyridine / 1.) 0 deg C , 1.5 h, 2.) room temperature, 1.5 h
View Scheme
参考文献
Alonso, Daniel; Font, Josep; Ortuno, Rosa M.
Journal of Organic Chemistry, 1991 , vol. 56, # 19 p. 5567 - 5572
