3-溴丙酮酸乙酯合成路线

参考文献

Kazock, Jean-Yves; Enguehard-Gueiffier, Cecile; Thery, Isabelle; Gueiffier, Alain
Bulletin of the Chemical Society of Japan, 2005 , vol. 78, # 1 p. 154 - 159

70-23-53-溴丙酮酸乙酯+

26060-30-04-硝基硫代苯甲酰胺

78979-64-32-(4-硝基苯基)-噻唑-4-羧酸乙酯

参考文献

Kadam, Kishorkumar S.; Jadhav, Ravindra D.; Kandre, Shivaji; Guha, Tandra; Reddy, M. Mahesh Kumar; Brahma, Manoja K.; Deshmukh, Nitin J.; Dixit, Amol; Doshi, Lalit; Srinivasan, Shaila; Devle, Jayendra; Damre, Anagha; Nemmani, Kumar V. S.; Gupte, Amol; Sharma, Rajiv
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 337 - 347

70-23-53-溴丙酮酸乙酯

64920-29-22-氧代-4-苯基丁酸乙酯

参考文献

Tetrahedron, , vol. 41, # 2 p. 467 - 472

70-23-53-溴丙酮酸乙酯+

765-87-71,2-环己二酮

56671-28-44-氧杂-4,5,6,7-四氢苯并[B]呋喃-3-羧酸

参考文献

US5723462 A1, ;
US 5723462 A

US5750702 A1, ;
US 5750702 A

70-23-53-溴丙酮酸乙酯+

504-02-91,3-环己二酮

56671-28-44-氧杂-4,5,6,7-四氢苯并[B]呋喃-3-羧酸

参考文献

Tetrahedron Letters, , vol. 49, # 3 p. 459 - 462

109-12-62-氨基嘧啶+

70-23-53-溴丙酮酸乙酯

64951-07-1咪唑并[1,2-a]嘧啶-3-羧酸乙酯+

64951-06-0咪唑并[1,2-a]嘧啶-2-甲酸乙酯

参考文献

WO2006/71752 A1, ;

Page/Page column 83 ;
WO 2006/071752 A1

109-12-62-氨基嘧啶+

70-23-53-溴丙酮酸乙酯

64951-06-0咪唑并[1,2-a]嘧啶-2-甲酸乙酯

参考文献

Rival; Grassy; Michel
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 5 p. 1170 - 1176

70-23-53-溴丙酮酸乙酯+

62-55-5硫代乙酰胺

6436-59-52-甲基噻唑-4-甲酸乙酯

参考文献

Zhan, Weiqiang; Jiang, Yi; Brodie, Peggy J.; Kingston, David G. I.; Liotta, Dennis C.; Snyder, James P.
Organic Letters, 2008 , vol. 10, # 8 p. 1565 - 1568

70-23-53-溴丙酮酸乙酯

6436-59-52-甲基噻唑-4-甲酸乙酯

参考文献

Reiner, John E.; Siev, Daniel V.; Araldi, Gian-Luca; Cui, Jingrong Jean; Ho, Jonathan Z.; Reddy, Komandla Malla; Mamedova, Lala; Vu, Phong H.; Lee, Kuen-Shan S.; Minami, Nathaniel K.; Gibson, Tony S.; Anderson, Susanne M.; Bradbury, Annette E.; Nolan, Thomas G.; Semple, J. Edward
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 8 p. 1203 - 1208

1072-98-62-氨基-5-氯吡啶+

70-23-53-溴丙酮酸乙酯

67625-38-16-氯咪唑[1,2-a]吡啶-2-羧酸乙基脂

参考文献

INCYTE CORPORATION; COMBS, Andrew P.; LI, Yun-Long; YUE, Eddy W.; SPARKS, Richard B.
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WO 2011/075643 A1