2-氨基-2-苯基乙酰胺合成路线 （共 68 条）
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / Cooling with ice; Reflux 1.2: 0 °C 2.1: ethanol / 2 h / Reflux 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / Cooling with ice; Reflux 3.2: 0 °C View Scheme
参考文献
AGIOS PHARMACEUTICALS, INC.; CAO, Sheldon; POPOVICI-MULLER, Janeta; SALITURO, Francesco G.; SAUNDERS, Jeffrey; TAN, Xuefei; TRAVINS, Jeremy; YAN, Shunqi; YE, Zhixiong
Patent: WO2012/171506 A1, 2012 ;
WO 2012/171506 A1
反应条件
potassium hydroxide; Alcaligenes faecalis penicillin acylase in water T=25°C; pH=10; 0.283333 h;
参考文献
Guranda, Dorel T.; Khimiuk, Andrey I.; Van Langen, Luuk M.; Van Rantwijk, Fred; Sheldon, Roger A.; Svedas, Vytas K.
Tetrahedron Asymmetry, 2004 , vol. 15, # 18 p. 2901 - 2906
反应条件
enzyme-substance from soil-bacteria lt;pseudomonasgt;
参考文献
Yakugaku Zasshi, , vol. 78, p. 767
Chem.Abstr., , p. 18237
反应条件
Rhodococcus sp. AJ270 in phosphate buffer T=30°C; pH=7.62; 2 h; Title compound not separated from byproducts;
参考文献
Tetrahedron Letters, , vol. 42, # 39 p. 6925 - 6927
反应条件
cobalt(II) chloride T=30°C; pH=8; aq. phosphate bufferResolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Molecular Catalysis B: Enzymatic, , vol. 74, # 3-4 p. 184 - 191
反应条件
1: hydrogenchloride / water / 3 h / 20 °C 2: PLP / aq. buffer / 24 h / 40 °C / pH 8.0 / |Enzymatic reaction View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 354, # 17 p. 3327 - 3332
反应条件
1: α-amino-2-phenylacetic acidamide hydrochloride With n-butyllithium in tetrahydrofuran; hexane T=20°C; 0.333333 h; 2: phosgene in toluene T=20°C; Further stages.;
参考文献
Kihlberg, Tor; Karimi, Farhad; Langstroem, Bengt
The Journal of organic chemistry, 2002 , vol. 67, # 11 p. 3687 - 3692
反应条件
Rhodococcus sp. AJ270 in phosphate buffer T=30°C; pH=7.62; 2 h; Title compound not separated from byproducts;
参考文献
Tetrahedron Letters, , vol. 42, # 39 p. 6925 - 6927
反应条件
cobalt(II) chloride T=30°C; pH=8; aq. phosphate bufferResolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Molecular Catalysis B: Enzymatic, , vol. 74, # 3-4 p. 184 - 191
反应条件
enzyme-substance from soil-bacteria lt;pseudomonasgt;
参考文献
Yakugaku Zasshi, , vol. 78, p. 767
Chem.Abstr., , p. 18237
