triethylamine in tetrahydrofuran; diethyl ether 1 h; Ambient temperature;

potassium phosphate; copper(l) iodide; N-methyl-2-(methylamino)ethylamine in N,N-dimethyl-formamide T=120°C; 24 h; Inert atmosphereSealed tube;

dicyclohexyl-carbodiimide in dichloromethane

n-butyllithium; iodine in tetrahydrofuran

1.1: n-BuLi; TMEDA / tetrahydrofuran / 2.25 h / -70 - -10 °C 1.2: 45 percent / 1,2-dibromoethane / tetrahydrofuran / 2.25 h / -70 - -10 °C 2.1: 76 percent / KOH / methanol / 4 h / Heating 3.1: 53 percent / t-BuONa; 1,1'-bis(diphenylphosphino)ferrocine / Pd2(dba)3 / toluene / 17 h / 100 °C 4.1: 61 percent / Na2CO3 / Pd(OAc)2 / dimethylformamide / Heating View Scheme

n-butyllithium; N,N,N',N,-tetramethylethylenediamine in diethyl ether; hexane 1.) -10 degC, 2 h, 2.) 1 h;

n-butyllithium; diethyl ether; d-N,a-dimethylphenethylamine 1.) THF, 0 deg C, 3h; 2.) -78 deg C to room temp.; Yield given. Multistep reaction;

暂无反应条件数据

1: With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran T=-78 - -10°C; 2.5 h; Inert atmosphere; 2: With iodine in tetrahydrofuran T=-78 - -65°C;

n-butyllithium; iodine in tetrahydrofuran