(4-甲氧羰基苯基)三氟硼酸钾合成路线 （共 16 条）
反应条件
potassium hydrogen difluoride in tetrahydrofuran 1 h; Inert atmosphere;
参考文献
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Patent: WO2009/137322 A2, 2009 ;
Location in patent: Page/Page column 19 ;
反应条件
1: With tetrahydroxydiboron; [1,3-bis(diphenylphosphino) propane] dichloronickel(II); N-ethyl-N,N-diisopropylamine; triphenylphosphine in ethanol T=20°C; Miyaura Borylation Reaction; 12 h; Inert atmosphereSealed tube; 2: With potassium hydrogen difluoride in methanol; ethanol; water T=0 - 20°C; 0.5 h;
参考文献
Molander, Gary A.; Cavalcanti, Livia N.; Garcia-Garcia, Carolina
Journal of Organic Chemistry, 2013 , vol. 78, # 13 p. 6427 - 6439
反应条件
1: With tetrahydroxydiboron; [1,3-bis(diphenylphosphino) propane] dichloronickel(II); N-ethyl-N,N-diisopropylamine; triphenylphosphine in ethanol T=80°C; Miyaura Borylation Reaction; 4 h; Inert atmosphereSealed tube; 2: With potassium hydrogen difluoride in methanol; ethanol; water T=0 - 20°C; 0.5 h;
参考文献
Molander, Gary A.; Cavalcanti, Livia N.; Garcia-Garcia, Carolina
Journal of Organic Chemistry, 2013 , vol. 78, # 13 p. 6427 - 6439
反应条件
PdCl(C6H4C6H4NH2)(Cy2PC6H4-2-C6H2-2',4',6'-i-Pr3); Cy2PC6H4-2-C6H2-2',4',6'-i-Pr3; K acetate in ethanol aryl bromide reacted with B2(OH)4 in EtOH in presence of catalyst (Pt-complex - ligand) and K acetate at 80°C for 3 h; subjected to aq. workup; treated with KHF2; purified by Soxlet extn.;
参考文献
Molander, Gary A.; Trice, Sarah L. J.; Kennedy, Steven M.; Dreher, Spencer D.; Tudge, Matthew T.
Journal of the American Chemical Society, 2012 , vol. 134, # 28 p. 11667 - 11673
反应条件
KHF2 in methanol; water T=0 - 20°C; 0.5 h; Inert atmosphere;
参考文献
Molander, Gary A.; Trice, Sarah L. J.; Kennedy, Steven M.; Dreher, Spencer D.; Tudge, Matthew T.
Journal of the American Chemical Society, 2012 , vol. 134, # 28 p. 11667 - 11673
反应条件
water in methanol T=0 - 20°C; 1 h; Inert atmosphere;
参考文献
European Journal of Organic Chemistry, , # 22 p. 4909 - 4917
反应条件
1: tetrahydroxydiboron; chloro(2-dicyclohexylphosphino-2',4',6'-triisoporpyl-1,1'-biphenyl)[2-(2'-amino-1,1'-biphenyl)] palladium (II); potassium acetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl / ethanol / 3 h / 80 °C / Inert atmosphere 2: KHF2 / methanol; water / 0.5 h / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Journal of the American Chemical Society, , vol. 134, # 28 p. 11667 - 11673
反应条件
sodium hypochlorite; water in water; ethyl acetate T=20°C; Open flask;
参考文献
Molander, Gary A.; Cavalcanti, Livia N.
Journal of Organic Chemistry, 2011 , vol. 76, # 17 p. 7195 - 7203
反应条件
(tBuCN)2CuOTf; 1-Fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate in ethyl acetate T=80°C; 12 h; Inert atmosphereGlovebox;
参考文献
Ye, Yingda; Sanford, Melanie S.
Journal of the American Chemical Society, 2013 , vol. 135, # 12 p. 4648 - 4651
反应条件
Oxonereg;; water in acetone T=20°C; 0.0333333 h;
参考文献
Journal of Organic Chemistry, , vol. 76, # 2 p. 623 - 630
