4-[5-[[2-(氮杂环庚-1-基)-5-氰基-1-乙基-4-甲基-6-氧代-吡啶-3-基]亚甲基]-4-氧代-2-硫代-噻唑烷-3-基]丁酸合成路线 （共 24 条）
反应条件
water; hydroxide in water T=25°C; Rate constant;
参考文献
Egan, Carmel; Clery, Maurice; Hegarty, Anthony F.; Welch, Alan J.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1991 , # 2 p. 249 - 256
反应条件
oxygen 1. chloroform, 0 degC, 1d; 2. chloroform, r.t., 3d; Yield given. Multistep reaction;
参考文献
De Sarlo, Francesco; Guarna, Antonio; Brandi, Alberto
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1505 - 1507
反应条件
in xylene 60 h; Heating;
参考文献
Hosomi, Akira; Shoji, Hiroaki; Sakurai, Hideki
Chemistry Letters, 1985 , p. 1049 - 1052
反应条件
sulfuric acid 2.) RT; Yield given. Multistep reaction;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 41, # 3 p. 478 - 480
参考文献
Kulu, Irem; Ocal, Nuket
Helvetica Chimica Acta, 2011 , vol. 94, # 11 p. 2054 - 2060
反应条件
chlorine; sodium hydrogencarbonate in water
T=0°C; 0.5 h;
参考文献
Conway, Gregory A.; Loeffler, Larry J.; Hall, Iris H.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 6 p. 876 - 884
反应条件
by Mukaiyama's method;
参考文献
Goti, Andrea; Brandi, Alberto; Sarlo, Francesco De; Guarna, Antonio
Tetrahedron Letters, 1986 , vol. 27, # 43 p. 5271 - 5274
反应条件
Heating; Yield given;
参考文献
Pasinszki; Westwood
Journal of Molecular Structure, 1997 , vol. 408-409, p. 161 - 169
反应条件
pyridine 1-oxide
Ambient temperatureIrradiation; Rate constantThermodynamic data;
参考文献
Bucher, Goetz; Scaiano, J. C.
Journal of Physical Chemistry, 1994 , vol. 98, # 48 p. 12471 - 12473
反应条件
acetyl chloride in N,N-dimethyl acetamide
T=20°C;
参考文献
Tyrkov
Russian Journal of Organic Chemistry, 2002 , vol. 38, # 8 p. 1218 - 1219
