3-甲基-1,3-二氮杂螺[4.5]癸烷-2,4-二酮合成路线 （共 6 条）
反应条件
potassium hydroxide in ethanol
24 h; Heating;
参考文献
Pedregal; Trigo; Espada; et al.
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 2 p. 477 - 480
反应条件
in N-methyl-acetamide
参考文献
Lilly Industries Limited
Patent: US4230709 A1, 1980 ;
反应条件
1: SOCl2 / r.t., 15 h, reflux, 1 h
2: 35 percent / pyridine / r.t., 12 h, reflux, 8 h
View Scheme
参考文献
Courtoison; Coudert; Couquelet; Tronche; Jonadet; Bastide
Farmaco, Edizione Scientifica, 1988 , vol. 43, # 2 p. 153 - 160
反应条件
in pyridine
r.t., 12 h, reflux, 8 h;
参考文献
Courtoison; Coudert; Couquelet; Tronche; Jonadet; Bastide
Farmaco, Edizione Scientifica, 1988 , vol. 43, # 2 p. 153 - 160
反应条件
sodium hydroxide
1) EtOH, reflux, 15 min; 2) reflux, 24 h; Yield given. Multistep reaction;
参考文献
Salazar, Loreto; Rubido, Julia; Espada, Modesta; Pedregal, Carmen; Trigo, Gregorio; Elguero, Jose
Journal of Heterocyclic Chemistry, 1986 , vol. 23, p. 481 - 485
参考文献
Carrington; Waring
Journal of the Chemical Society, 1950 , p. 354,366
