1-(4-氟-苯基)-1-戊酮合成路线 （共 11 条）
反应条件
1: 50 g / dimethylsulfoxide / 5 h / 110 - 130 °C 2: 16 g / 30percent KOH / ethanol / Heating 3: 9.4 g / sodium bicarbonate / dimethylformamide / 18 h / Ambient temperature View Scheme
参考文献
Wagner, Peter J.; Siebert, Elizabeth J.
Journal of the American Chemical Society, 1981 , vol. 103, # 24 p. 7329 - 7335
反应条件
in dimethyl sulfoxide T=110 - 130°C; 5 h;
参考文献
Wagner, Peter J.; Siebert, Elizabeth J.
Journal of the American Chemical Society, 1981 , vol. 103, # 24 p. 7329 - 7335
反应条件
1: n-butyl-triphenylphosphonium bromide With n-butyllithium in tetrahydrofuran; hexane
T=-15°C;
2: 4-fluoro-N-methoxy-N-methyl-benzamide in tetrahydrofuran; hexane
T=-78 - 20°C; Wittig reaction;
3: With hydrogenchloride in tetrahydrofuran; diethyl ether; hexane
T=20°C;
参考文献
Murphy, John A.; Commeureuc, Aurelien G. J.; Snaddon, Thomas N.; McGuire, Thomas M.; Khan, Tanweer A.; Hisler, Kevin; Dewis, Mark L.; Carling, Robert
Organic Letters, 2005 , vol. 7, # 7 p. 1427 - 1429
反应条件
1: n-butyllithium With copper (I) cyanide in diethyl ether; hexane
T=0°C; 0.0833333 h; Inert atmosphere;
2: 4-fluoro-benzoic acid in diethyl ether; hexane
T=0 - 20°C; 15 h; Inert atmosphere;
参考文献
Genna, Douglas T.; Posner, Gary H.
Organic Letters, 2011 , vol. 13, # 19 p. 5358 - 5361
反应条件
1: 4-fluoro-benzoyl chloride With morpholine; diisobutylaluminium hydride in tetrahydrofuran; hexane
T=0°C; 0.166667 h; Inert atmosphere;
2: n-butyllithium in tetrahydrofuran; hexane
T=0°C; 0.166667 h;
参考文献
Park, Jae Kyo; Shin, Won Kyu; An, Duk Keun
Tetrahedron Letters, 2013 , vol. 54, # 24 p. 3199 - 3203
反应条件
potassium fluoride; C94H134O4P2Pd2; silver fluoride in cyclohexane
T=110°C; 14 h; Sealed tube;
参考文献
Lee, Hong Geun; Milner, Phillip J.; Buchwald, Stephen L.
Journal of the American Chemical Society, 2014 , vol. 136, # 10 p. 3792 - 3795
反应条件
1.1: 94 percent / tetrahydrofuran / -78 °C
2.1: n-BuLi / tetrahydrofuran; hexane / -15 °C
2.2: tetrahydrofuran; hexane / -78 - 20 °C
2.3: 78 percent / aq. HCl / tetrahydrofuran; hexane; diethyl ether / 20 °C
View Scheme
参考文献
Murphy, John A.; Commeureuc, Aurelien G. J.; Snaddon, Thomas N.; McGuire, Thomas M.; Khan, Tanweer A.; Hisler, Kevin; Dewis, Mark L.; Carling, Robert
Organic Letters, 2005 , vol. 7, # 7 p. 1427 - 1429
反应条件
aluminium trichloride
参考文献
de Roocker,A.; de Radzitzky,P.
Bulletin des Societes Chimiques Belges, 1963 , vol. 72, p. 202 - 207
反应条件
1: 51 percent / 1.) LDA / tetrahydrofuran / 0.42 h / -65 °C
2: 4 eq. t-BuLi / tetrahydrofuran / -70 °C
View Scheme
参考文献
Satoh, Tsuyoshi; Itoh, Norifumi; Gengyo, Kaoru; Takada, Sae; Asakawa, Naoyuki; et al.
Tetrahedron, 1994 , vol. 50, # 41 p. 11839 - 11852
反应条件
Irradiation; Rate constant;
参考文献
Kimura, Norio; Takamuku, Setsuo
Journal of the American Chemical Society, 1994 , vol. 116, # 9 p. 4087 - 4088
