1: tetrahydrofuran; hexane / 0.17 h / -78 °C / |Inert atmosphere 2: tetrahydrofuran; hexane / 0.5 h / |Inert atmosphere 3: Cl2Ni(1,2-bis(diphenylphosphino)ethane) / tetrahydrofuran / 5 h / |Inert atmosphere; |Reflux 4: water; hydrogenchloride / 3 h / |Reflux View Scheme

1.1: tetrahydrofuran; hexane / 0.17 h / 0 - 20 °C / |Inert atmosphere 1.2: 2 h / |Reflux; |Inert atmosphere 2.1: tetrahydrofuran; hexane / 0.17 h / -78 °C / |Inert atmosphere 3.1: tetrahydrofuran; hexane / 0.5 h / |Inert atmosphere 4.1: Cl2Ni(1,2-bis(diphenylphosphino)ethane) / tetrahydrofuran / 5 h / |Inert atmosphere; |Reflux 5.1: water; hydrogenchloride / 3 h / |Reflux View Scheme

1.1: hydrogenchloride / water / 20 °C 2.1: AlCl3, aluminium chloride / dichloromethane / |Reflux 3.1: palladium dichloride; copper(l) iodide; triethylamine / methanol / 20 °C / |Sonication 4.1: sodium hydride / toluene / |Reflux 4.2: 20 °C 5.1: n-butyllithium / tetrahydrofuran / -78 °C 5.2: 20 °C 6.1: tetrahydrofuran; hexane / 0.17 h / 0 - 20 °C / |Inert atmosphere 6.2: 2 h / |Reflux; |Inert atmosphere 7.1: tetrahydrofuran; hexane / 0.17 h / -78 °C / |Inert atmosphere 8.1: tetrahydrofuran; hexane / 0.5 h / |Inert atmosphere 9.1: Cl2Ni(1,2-bis(diphenylphosphino)ethane) / tetrahydrofuran / 5 h / |Inert atmosphere; |Reflux 10.1: water; hydrogenchloride / 3 h / |Reflux View Scheme

1.1: AlCl3, aluminium chloride / dichloromethane / |Reflux 2.1: palladium dichloride; copper(l) iodide; triethylamine / methanol / 20 °C / |Sonication 3.1: sodium hydride / toluene / |Reflux 3.2: 20 °C 4.1: n-butyllithium / tetrahydrofuran / -78 °C 4.2: 20 °C 5.1: tetrahydrofuran; hexane / 0.17 h / 0 - 20 °C / |Inert atmosphere 5.2: 2 h / |Reflux; |Inert atmosphere 6.1: tetrahydrofuran; hexane / 0.17 h / -78 °C / |Inert atmosphere 7.1: tetrahydrofuran; hexane / 0.5 h / |Inert atmosphere 8.1: Cl2Ni(1,2-bis(diphenylphosphino)ethane) / tetrahydrofuran / 5 h / |Inert atmosphere; |Reflux 9.1: water; hydrogenchloride / 3 h / |Reflux View Scheme

1.1: palladium dichloride; copper(l) iodide; triethylamine / methanol / 20 °C / |Sonication 2.1: sodium hydride / toluene / |Reflux 2.2: 20 °C 3.1: n-butyllithium / tetrahydrofuran / -78 °C 3.2: 20 °C 4.1: tetrahydrofuran; hexane / 0.17 h / 0 - 20 °C / |Inert atmosphere 4.2: 2 h / |Reflux; |Inert atmosphere 5.1: tetrahydrofuran; hexane / 0.17 h / -78 °C / |Inert atmosphere 6.1: tetrahydrofuran; hexane / 0.5 h / |Inert atmosphere 7.1: Cl2Ni(1,2-bis(diphenylphosphino)ethane) / tetrahydrofuran / 5 h / |Inert atmosphere; |Reflux 8.1: water; hydrogenchloride / 3 h / |Reflux View Scheme

1.1: sodium hydride / toluene / |Reflux 1.2: 20 °C 2.1: n-butyllithium / tetrahydrofuran / -78 °C 2.2: 20 °C 3.1: tetrahydrofuran; hexane / 0.17 h / 0 - 20 °C / |Inert atmosphere 3.2: 2 h / |Reflux; |Inert atmosphere 4.1: tetrahydrofuran; hexane / 0.17 h / -78 °C / |Inert atmosphere 5.1: tetrahydrofuran; hexane / 0.5 h / |Inert atmosphere 6.1: Cl2Ni(1,2-bis(diphenylphosphino)ethane) / tetrahydrofuran / 5 h / |Inert atmosphere; |Reflux 7.1: water; hydrogenchloride / 3 h / |Reflux View Scheme

1: Cl2Ni(1,2-bis(diphenylphosphino)ethane) / tetrahydrofuran / 5 h / |Inert atmosphere; |Reflux 2: water; hydrogenchloride / 3 h / |Reflux View Scheme