1: sodium carbonate; acetic acid / dichloromethane; water / 6 h / 15 - 25 °C 2: sodium hydroxide; tri-n-butylmethylammonium chloride / water / 4 h / 60 °C / |Large scale 3: triethylamine / ethyl acetate / 0.42 h / -15 °C 4: triethylamine / ethyl acetate / 0.25 h / -15 °C 5: hydrogenchloride / water; ethyl acetate / 0.5 h / 15 - 25 °C 6: sodium hydroxide; tri-n-butylmethylammonium chloride / water / 2 h / 20 - 25 °C / |Large scale 7: ammonium hydroxide / methanol / 3 h / 40 °C / |Large scale 8: dichloromethane; isopropyl alcohol / 5 h / |Large scale 9: triethylamine; carbonic acid dimethyl ester / 0.5 h / 4 - 10 °C / |Large scale 10: potassium tert-butylate / isopropyl alcohol; tert-butyl alcohol / 1 h / 20 °C / |Large scale 11: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 0.25 h / 10 °C / |Large scale View Scheme

1: triethylamine; carbonic acid dimethyl ester / 0.5 h / 4 - 10 °C / |Large scale 2: potassium tert-butylate / isopropyl alcohol; tert-butyl alcohol / 1 h / 20 °C / |Large scale 3: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 0.25 h / 10 °C / |Large scale View Scheme

in ethyl acetate Ambient temperature; Yield given;