4,4-二甲基-2-(2-甲基苯基)-4,5-二氢-1,3-噁唑合成路线 （共 17 条）
反应条件
n-butyllithium in diethyl ether
Inert atmosphere;
参考文献
Sharma, Arvind Kumar; Maheshwary, Yogita; Singh, Paramjit; Singh, Kamal Nain
Arkivoc, 2010 , vol. 2010, # 9 p. 54 - 62
反应条件
n-butyllithium
1.) ethyl ether, 0 deg C, 1 h, 2.) RT, overnight; Yield given. Multistep reaction;
参考文献
Fu; Unruh; Miller; et al.
Journal of Organic Chemistry, 1985 , vol. 50, # 8 p. 1259 - 1261
反应条件
n-butyllithium
1.) ethyl ether, 0 deg C, 1 h, 2.) RT, overnight; Yield given. Multistep reaction;
参考文献
Fu; Unruh; Miller; et al.
Journal of Organic Chemistry, 1985 , vol. 50, # 8 p. 1259 - 1261
反应条件
1.1: sBuLi / tetrahydrofuran; cyclohexane; hexane / -78 °C
2.1: sBuLi; B(OMe)3 / tetrahydrofuran; cyclohexane; hexane / -78 - 20 °C
2.2: H2O2 / acetic acid / 20 °C
2.3: TFA / tetrahydrofuran; H2O / Heating
View Scheme
参考文献
Tahara, Naruki; Fukuda, Tsutomu; Iwao, Masatomo
Tetrahedron Letters, 2004 , vol. 45, # 26 p. 5117 - 5120
反应条件
(i) nBuLi, hexane, Et2O, (ii) /BRN= 605308/; Multistep reaction;
参考文献
Gschwend,H.W.; Hamdan,A.
Journal of Organic Chemistry, 1975 , vol. 40, # 13 p. 2008 - 2009
反应条件
1: 1.) n-BuLi / 1.) THF, from -40 to -10 deg C, 2.) THF, RT, 30 min
2: 86 percent / conc. aq. HCl / 24 h / Heating
3: SOCl2
View Scheme
参考文献
Griffiths, D. Vaughan; Griffiths, Penelope A.; Karim, Khalku; Whitehead, Belinda J.
Journal of Chemical Research, Miniprint, 1996 , # 4 p. 901 - 925
反应条件
1.1: sBuLi / tetrahydrofuran; cyclohexane; hexane / -78 °C
2.1: sBuLi; B(OMe)3 / tetrahydrofuran; cyclohexane; hexane / -78 - 20 °C
2.2: H2O2 / acetic acid / 20 °C
2.3: TFA / tetrahydrofuran; H2O / Heating
View Scheme
参考文献
Tahara, Naruki; Fukuda, Tsutomu; Iwao, Masatomo
Tetrahedron Letters, 2004 , vol. 45, # 26 p. 5117 - 5120
