2-氨基-5-氯二苯甲酮合成路线 （共 174 条）
反应条件
1: toluene / 3.5 h / 10 - 20 °C 2: 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane; ammonium acetate / ethanol / 6 h / |Reflux 3: dipotassium peroxodisulfate; iodine / acetic acid / 8 h / 65 - 70 °C View Scheme
参考文献
Cepanec, Ivica; Litvic, Mladen; Pogorelic, Ivan
Organic Process Research and Development, 2006 , vol. 10, # 6 p. 1192 - 1198
反应条件
1: toluene / 3.5 h / 10 - 20 °C 2: 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane; ammonium acetate / ethanol / 6 h / |Reflux 3: dipotassium peroxodisulfate; iodine / acetic acid / 8 h / 65 - 70 °C 4: sodium hydroxide; water / ethanol / 1.5 h / 5 °C View Scheme
参考文献
Cepanec, Ivica; Litvic, Mladen; Pogorelic, Ivan
Organic Process Research and Development, 2006 , vol. 10, # 6 p. 1192 - 1198
反应条件
peroxymonosulfuric acid
参考文献
Giovannini,E.; de Sousa,B.F.S.E.
Helvetica Chimica Acta, 1979 , vol. 62, p. 185 - 197
反应条件
1: 99 percent / NaBH4 / propan-2-ol / 3.5 h / 60 °C 2: 80 percent / Et3N / benzene / 2 h / 5 °C 3: 65 percent / KOH / ethanol / 4 h / Heating View Scheme
参考文献
Aver'yanova; Sevodin
Russian Journal of Organic Chemistry, 2006 , vol. 42, # 9 p. 1417 - 1419
反应条件
sodium hydrogencarbonate in formic acid; water; ethyl acetate
参考文献
Takeda Chemical Industries, Ltd.
Patent: US4082764 A1, 1978 ;
反应条件
T=117°C; 24 h; RefluxInert atmosphere;
参考文献
GENZYME CORPORATION; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; MAZITSCHEK, Ralph; CLARDY, Jon, C.; WIRTH, Dyann; WIEGAND, Roger; URGAONKAR, Sameer; BANIECKI, Mary, Lynn; CORTESE, Joseph; CELATKA, Cassandra; XIANG, Yibin; SKERLJ, Renato; BOURQUE, Elyse, M.j.
Patent: WO2011/53697 A1, 2011 ;
Location in patent: Page/Page column 75-76 ;
反应条件
ammonium acetate in ethanol; water 0.25 h;
参考文献
Hoefnagel; Van Koningsveld; Van Meurs; Peters; Sinnema; Van Bekkum
Tetrahedron, 1993 , vol. 49, # 31 p. 6899 - 6912
反应条件
2: sodium ethoxide 3: 87 percent / phosphorus oxychloride View Scheme
参考文献
Hino; Furukawa; Nagai; Uno
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 9 p. 2618 - 2622
反应条件
1: With dicyclohexyl-carbodiimide in toluene T=150°C; 0.5 h; Microwave irradiation; 2: With trifluoroacetic acid in toluene T=150°C; 0.333333 h; Microwave irradiation;
参考文献
New Journal of Chemistry, , vol. 35, # 11 p. 2412 - 2415
