2-氨基-5-氯二苯甲酮合成路线 （共 174 条）
反应条件
1: With sodium hydrogencarbonate in chloroform T=0 - 20°C; 2: With ammonia in methanol; chloroform T=0°C; Reflux;
参考文献
Journal of Organic Chemistry, , vol. 78, # 20 p. 10310 - 10318
反应条件
in pyridine Heating;
参考文献
Angewandte Chemie - International Edition, , vol. 40, # 6 p. 1053 - 1055
反应条件
in pyridine Heating;
参考文献
Journal of Heterocyclic Chemistry, , vol. 25, p. 459 - 462
反应条件
tetrafluoroboric acid; N,N-dimethyl-formamide; sodium nitrite 1) water, 0 deg C, 2 h, 2) 50 deg C, 120 min; Yield given. Multistep reaction;
参考文献
Lahoti, R. J.; Parameswaran, V.; Wagle, D. R.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 9 p. 767 - 769
反应条件
1: 1.) conc. H2SO4, NaNO2, 2.) Na2CO3, CuSO4*5H2O / 1.) glacial acetic acid, H2O, from 0 deg C to 5 deg C, 2.) H2O, 10 deg C 2: 84 percent / conc. aq. H2SO4 / H2O / 6 h / Heating View Scheme
参考文献
Fontanella; Mariani
Farmaco, Edizione Scientifica, 1975 , vol. 30, # 10 p. 773 - 788
反应条件
PPE in neat (no solvent) T=120 - 125°C; 0.5 h;
参考文献
Wakankar, D. M.; Hosangadi, B. D.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 8 p. 703 - 704
反应条件
toluene-4-sulfonic acid; 1,2-diamino-benzene in toluene 138 h; Heating;
参考文献
Peet, Norton P.; Sunder, Shyam; Barbuch, Robert J.; Whalon, Michael R.; Huber, Edward W.; Huffman, John C.
Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 1611 - 1618
反应条件
toluene-4-sulfonic acid in toluene 138 h; Heating;
参考文献
Peet, Norton P.; Sunder, Shyam; Barbuch, Robert J.; Whalon, Michael R.; Huber, Edward W.; Huffman, John C.
Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 1611 - 1618
反应条件
aluminium trichloride 1.) 25 deg C, 1 h, 2.) ether, room temp., 3 h; Yield given. Multistep reaction;
参考文献
Acharya, Baman Prasad; Rao, Y. Ramachandra
Journal of Chemical Research, Miniprint, 1987 , # 4 p. 1001 - 1035
反应条件
sodium ethanolate in ethanol 48 h; Heating;
参考文献
Gilead Palo Alto, Inc.
Patent: US2010/125091 A1, 2010 ;
Location in patent: Page/Page column 16 ;
