2-氨基-5-氯二苯甲酮合成路线 （共 174 条）
反应条件
1: 1.) sodium nitrite, conc. sulfuric acid, 2.) aq. potassium iodide / 1.) 1 h, 2.) room temp., overnight
2: 46 percent / triphenylphosphine, palladium chloride, cuprous iodide, diethylamine / CH2Cl2 / 20 h / Ambient temperature
3: 80 percent / 40percent aq. methylamine / aq. ethanol / 2 h / Ambient temperature
View Scheme
参考文献
Trybulski, Eugene J.; Reeder, Earl; Blount, John F.; Walser, Armin; Fryer, R. Ian
Journal of Organic Chemistry, 1982 , vol. 47, # 12 p. 2441 - 2447
反应条件
in toluene
2 h; Heating;
参考文献
Schlitzer, Martin; Sattler, Isabel; Dahse, Hans-Martin
Archiv der Pharmazie, 1999 , vol. 332, # 4 p. 124 - 132
反应条件
1: 89 percent / NH2OH*HCl / aq. ethanol / 10 h / Heating
2: 74 percent / acetic acid / 0.17 h / 50 °C
3: 96 percent / NH3 / methanol / 72 h / Ambient temperature
View Scheme
参考文献
Lessel
Archiv der Pharmazie, 1994 , vol. 327, # 2 p. 77 - 84
反应条件
1: 95 percent / Na-Hg / ethanol / 9 h / 80 °C
2: 85 percent / aq. HCl / 1.5 h / 80 °C
View Scheme
参考文献
Richter; Oertel
Pharmazie, 1990 , vol. 45, # 10 p. 721 - 724
参考文献
The Dow Chemical Company
Patent: US4144233 A1, 1979 ;
反应条件
1-n-butyl-3-methylimidazolium chloride; zinc(II) chloride
T=20°C; Friedlaender synthesis; 24 h;
参考文献
Karthikeyan, Ganesan; Perumal, Paramasivan T.
Journal of Heterocyclic Chemistry, 2004 , vol. 41, # 6 p. 1039 - 1041
反应条件
1: With hydrogen bromide; sodium nitrite in water
T=-10°C; 0.5 h;
2: With hydrogen bromide; copper(I) bromide in water
T=-10 - 55°C; 0.333333 h;
参考文献
CHEMOCENTRYX, INC.
Patent: WO2003/105853 A1, 2003 ;
Location in patent: Page 58-59 ;
WO 03/105853 A1
反应条件
1: 94 percent Turnov. / ammonium acetate / H2O; ethanol / 0.25 h
2: 82 percent / 2 N NaOH / ethanol / 1 h / Heating
View Scheme
参考文献
Hoefnagel; Van Koningsveld; Van Meurs; Peters; Sinnema; Van Bekkum
Tetrahedron, 1993 , vol. 49, # 31 p. 6899 - 6912
反应条件
1: in dichloromethane
T=0 - 25°C;
2: With water in dichloromethane
T=25°C; 5 h;
参考文献
Barthel, Alexander; Trieschmann, Lothar; Stroehl, Dieter; Kluge, Ralph; Boehm, Gerald; Csuk, Rene
Archiv der Pharmazie, 2009 , vol. 342, # 8 p. 445 - 452
反应条件
chlorosulphonyl isocyanate in benzene
参考文献
Kamal, Ahmed; Rao, K. Rama; Sattur, P. B.
Synthetic Communications, 1980 , vol. 10, # 10 p. 799 - 804
