2-氨基-5-氯二苯甲酮合成路线 （共 174 条）
反应条件
in dichloromethane; water
参考文献
Merck Patent Gesellschaft mit beschraenkter Haftung
Patent: US4232016 A1, 1980 ;
反应条件
in ethanol; chloroform; dimethyl sulfoxide
参考文献
Merck Patent Gesellschaft mit beschraenkter Haftung
Patent: US4232016 A1, 1980 ;
反应条件
1: tert-butyl hypochlorite / CH2Cl2 / 1 h / -70 °C
2: Et3N / CH2Cl2 / -70 - 20 °C
3: 3N aq. HCl / CH2Cl2 / 2 h / Heating
4: 25 percent / Sn, conc. aq. HCl / ethanol / 18 h / Heating
View Scheme
参考文献
Walsh; Moran; Shamblee; Uwaydah; Welstead Jr.; Sancilio; Dannenburg
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1379 - 1388
反应条件
1: 94 percent Turnov. / ammonium acetate / H2O; ethanol / 0.25 h
2: 87 percent / air / dimethylformamide / 72 h / Irradiation
3: 82 percent / HCl gas / 3 h / Heating
View Scheme
参考文献
Hoefnagel; Van Koningsveld; Van Meurs; Peters; Sinnema; Van Bekkum
Tetrahedron, 1993 , vol. 49, # 31 p. 6899 - 6912
反应条件
sodium hydrogencarbonate in N-methyl-acetamide; ice-water; hexane
参考文献
Takeda Chemical Industries, Ltd.
Patent: US4082764 A1, 1978 ;
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in ethanol
T=20°C; 12 h;
参考文献
Shibata; Das; Harada; Takeuchi; Bando
Synlett, 2001 , # 11 p. 1755 - 1758
反应条件
1: CHCl3
2: aq. NaOH
3: Et3N
4: NH2OH*HCl, aq. NaOH / 2-methoxy-ethanol
View Scheme
参考文献
Bell,S.C. et al.
Journal of Heterocyclic Chemistry, 1967 , vol. 4, p. 647 - 649
反应条件
hydrogenchloride in methanol; water
T=80°C; 840 h; Title compound not separated from byproducts;
参考文献
Nudelman, N. Sbarbati; Waisbaum, R. G. de
Journal of Physical Organic Chemistry, 1997 , vol. 10, # 2 p. 97 - 106
反应条件
hydrogenchloride in water
T=80°C; 840 h; Title compound not separated from byproducts;
参考文献
Nudelman, N. Sbarbati; Waisbaum, R. G. de
Journal of Physical Organic Chemistry, 1997 , vol. 10, # 2 p. 97 - 106
反应条件
1: H2SO5
2: aq. HCl / Irradiation
View Scheme
参考文献
Giovannini,E.; de Sousa,B.F.S.E.
Helvetica Chimica Acta, 1979 , vol. 62, p. 185 - 197
