2-氨基-5-氯二苯甲酮合成路线 （共 174 条）
反应条件
1: 89 percent / NH2OH*HCl / aq. ethanol / 10 h / Heating 2: 74 percent / acetic acid / 0.17 h / 50 °C View Scheme
参考文献
Lessel
Archiv der Pharmazie, 1994 , vol. 327, # 2 p. 77 - 84
反应条件
potassium carbonate in acetonitrile T=25°C; 1 h;
参考文献
Bergagnini, MacKenzie; Fukushi, Kazunobu; Han, Jianlin; Shibata, Norio; Roussel, Christian; Ellis, Trevor K.; Acena, Jose Luis; Soloshonok, Vadim A.
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 8 p. 1278 - 1291
反应条件
in toluene T=10 - 20°C; 3.5 h;
参考文献
Cepanec, Ivica; Litvic, Mladen; Pogorelic, Ivan
Organic Process Research and Development, 2006 , vol. 10, # 6 p. 1192 - 1198
反应条件
[HBIM](1+)*BF4(1-) T=100°C; Friedlaender reaction; 6 h;
参考文献
Palimkar, Sanjay S.; Siddiqui, Shapi A.; Daniel, Thomas; Lahoti, Rajgopal J.; Srinivasan, Kumar V.
Journal of Organic Chemistry, 2003 , vol. 68, # 24 p. 9371 - 9378
反应条件
lithium diisopropyl amide 1) THF, 0 deg C, 45 min.; 2) 60 min.; Yield given. Multistep reaction;
参考文献
Park, Dorothy J.; Fulmer, Tammy D.; Beam, Charles F.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 649 - 652
反应条件
anhydrous magnesium perchlorate in ethanol T=60°C; Friedlaender synthesis; 18 h;
参考文献
Soleimani, Ebrahim; Khodaei, Mohammad Mehdi; Batooie, Nasim; Samadi, Saadi
Chemical and Pharmaceutical Bulletin, 2010 , vol. 58, # 2 p. 212 - 213
反应条件
sodium salt of sulfated chitosan in ethanol T=50°C; Friedlaender Quinoline Synthesis; 0.333333 h;
参考文献
Reddy, B.V. Subba; Venkateswarlu; Reddy, G. Niranjan; Reddy, Y.V. Rami
Tetrahedron Letters, 2013 , vol. 54, # 43 p. 5767 - 5770
反应条件
copper(II) bis(trifluoromethanesulfonate) in neat (no solvent) T=110°C; 3 h;
参考文献
Bagdi, Avik Kumar; Santra, Sougata; Rahman, Matiur; Majee, Adinath; Hajra, Alakananda
RSC Advances, 2013 , vol. 3, # 46 p. 24034 - 24037
反应条件
sulfuric acid; silica gel T=100°C; Friedlaender synthesis; 0.75 h;
参考文献
Shaabani, Ahmad; Soleimani, Ebrahim; Badri, Zahra
Monatshefte fur Chemie, 2006 , vol. 137, # 2 p. 181 - 184
反应条件
in toluene 1.5 h; Heating / reflux;
参考文献
BIOLIPOX AB; MCNEENEY, Stephen, Phillip
Patent: WO2005/5415 A1, 2005 ;
Location in patent: Page/Page column 54-55 ;
WO 2005/005415 A1
