3-哌啶甲酸乙酯（盐酸盐）合成路线

参考文献

Orjales, Aurelio; Mosquera, Ramon; Toledo, Antonio; Pumar, M. Carmen; Garcia, Neftali; Cortizo, Lourdes; Labeaga, Luis; Innerarity, Ana
Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5512 - 5532

71962-74-83-哌啶甲酸乙酯（盐酸盐）

72551-53-21-苄基-3-哌啶甲酸乙酯

参考文献

Ram, Siya; Spicer, Leonard D.
Tetrahedron Letters, 1987 , vol. 28, # 5 p. 515 - 516

140-88-5丙烯酸乙酯+

71962-74-83-哌啶甲酸乙酯（盐酸盐）

128200-19-1

参考文献

Palmer, Richard Michael John; Meyers, Nicholas Leslie; Knight, John
Patent: US2005/49416 A1, 2005 ;
Location in patent: Page/Page column 7 ;

539-74-23-溴丙酸乙酯+

71962-74-83-哌啶甲酸乙酯（盐酸盐）

128200-19-1

参考文献

Callen, Gary; Chorghade, Mukund S.; Lee, Elaine C.; Nielsen, Peter G.; Petersen, Hans; Rustum, Abu
Heterocycles, 1994 , vol. 39, # 1 p. 293 - 304

623-71-23-氯丙酸乙酯+

71962-74-83-哌啶甲酸乙酯（盐酸盐）

128200-19-1

参考文献

Clemo et al.
Journal of the Chemical Society, 1931 , p. 3190,3197

106-94-5溴丙烷+

71962-74-83-哌啶甲酸乙酯（盐酸盐）

100050-04-2

参考文献

Jaen, Juan C.; Wise, Lawrence D.; Caprathe, Bradley W.; Tecle, Haile; Bergmeier, Stephen; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 311 - 317

71962-74-83-哌啶甲酸乙酯（盐酸盐）

71381-75-41-BOC-哌啶-3-羧酸

参考文献

Villalgordo, Jose M.; Heimgartner, Heinz
Tetrahedron, 1993 , vol. 49, # 33 p. 7215 - 7222

71962-74-83-哌啶甲酸乙酯（盐酸盐）

110-89-4哌啶+

54509-73-8+

124-38-9二氧化碳

参考文献

Monsalve, Angiebelk; Rosas, Felix; Tosta, Maria; Herize, Armando; Dominguez, Rosa M.; Brusco, Doris; Chuchani, Gabriel
International Journal of Chemical Kinetics, 2006 , vol. 38, # 2 p. 106 - 114

71962-74-83-哌啶甲酸乙酯（盐酸盐）

116574-71-1N-Boc-3-哌啶甲醇

参考文献

Slusarchyk, William A.; Bolton, Scott A.; Hartl, Karen S.; Huang, Ming-Hsing; Jacobs, Glenn; Meng, Wei; Ogletree, Martin L.; Pi, Zulan; Schumacher, William A.; Seiler, Steven M.; Sutton, James C.; Treuner, Uwe; Zahler, Robert; Zhao, Guohua; Bisacchi, Gregory S.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 21 p. 3235 - 3238

24424-99-5二碳酸二叔丁酯+

71962-74-83-哌啶甲酸乙酯（盐酸盐）

148672-74-6

参考文献

VITAE PHARMACEUTICALS, INC.
Patent: WO2007/117560 A2, 2007 ;
Location in patent: Page/Page column 126 ;
WO 2007/117560 A2