3-哌啶甲酸乙酯（盐酸盐）合成路线 （共 72 条）
反应条件
diisobutylaluminium hydride in toluene
T=-78°C; 2 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2004/5255 A1, 2004 ;
Location in patent: Page 44 ;
WO 2004/005255 A1
反应条件
kieselguhr; ethanol; nickel
T=250°C; P=147102 - 220652 Torr; Hydrogenation;
参考文献
Folkers; Adkins
Journal of the American Chemical Society, 1932 , vol. 54, p. 1146
反应条件
N-phenyl carbamic acid isopropyl ester; hydrogen; [Rh(μ-Cl)(2,5-norbornadiene)]2 in tetrahydrofuran
T=60°C; P=75006 Torr; 18 h; Product distribution; Further Variations:ReagentsSolvents;
参考文献
Studer, Martin; Wedemeyer-Exl, Christina; Spindler, Felix; Blaser, Hans-Ulrich
Monatshefte fur Chemie, 2000 , vol. 131, # 12 p. 1335 - 1343
反应条件
1: Hydrogenation
2: hydrochloric acid
View Scheme
参考文献
McElvain; Adams
Journal of the American Chemical Society, 1923 , vol. 45, p. 2740,2747
参考文献
McElvain; Adams
Journal of the American Chemical Society, 1923 , vol. 45, p. 2740,2747
反应条件
1.1: sodium ethanolate / ethanol; water / 1 h / |Reflux
1.2: 20 °C
1.3: |Reflux
2.1: sodium carbonate / water; tert-butyl methyl ether
View Scheme
参考文献
Moher, Eric D.; Tripp, Allie E.; Creemer, Lawrence C.; Vicenzi, Jeffrey T.
Organic Process Research and Development, 2004 , vol. 8, # 4 p. 593 - 596
反应条件
T=165°C; P=110326 - 220652 Torr; Hydrogenation;
参考文献
Adkins et al.
Journal of the American Chemical Society, 1934 , vol. 56, p. 2425,2427
反应条件
T=165°C; P=110326 - 220652 Torr; Hydrogenation;
参考文献
Adkins et al.
Journal of the American Chemical Society, 1934 , vol. 56, p. 2425,2427
反应条件
T=165°C; P=110326 - 220652 Torr; Hydrogenation;
参考文献
Adkins et al.
Journal of the American Chemical Society, 1934 , vol. 56, p. 2425,2427
反应条件
T=250°C; P=147102 - 220652 Torr; Hydrogenation;
参考文献
Folkers; Adkins
Journal of the American Chemical Society, 1932 , vol. 54, p. 1146
