1-(2-甲基苯基)哌啶合成路线 （共 13 条）
反应条件
(CuOTf)2.C6H6 in tetrahydrofuran
T=25°C; 1 h;
参考文献
Berman, Ashley M.; Johnson, Jeffrey S.
Journal of the American Chemical Society, 2004 , vol. 126, # 18 p. 5680 - 5681
反应条件
sodium t-butanolate; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; (Me)CgPPh in toluene
T=30°C;
参考文献
Gerristma, David; Brenstrum, Timothy; McNulty, James; Capretta, Alfredo
Tetrahedron Letters, 2004 , vol. 45, # 45 p. 8319 - 8321
反应条件
sodium t-butanolate; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; (Me)CgPPh in toluene
T=50°C;
参考文献
Gerristma, David; Brenstrum, Timothy; McNulty, James; Capretta, Alfredo
Tetrahedron Letters, 2004 , vol. 45, # 45 p. 8319 - 8321
反应条件
tris(triphenylphosphine)ruthenium(II) chloride in 1,4-dioxane
T=150°C; 5 h;
参考文献
Tsuji, Yasushi; Huh, Keun-Tae; Ohsugi, Yukihiro; Watanabe, Yoshihisa
Journal of Organic Chemistry, 1985 , vol. 50, # 9 p. 1365 - 1370
反应条件
copper dichloride in tetrahydrofuran
T=20°C; 0.25 h;
参考文献
Campbell, Matthew J.; Johnson, Jeffrey S.
Organic Letters, 2007 , vol. 9, # 8 p. 1521 - 1524
反应条件
sodium carbonate; toluene
参考文献
Sommers; Aaland
Journal of the American Chemical Society, 1953 , vol. 75, p. 5280,5282
反应条件
[Pd(Amphos)(cinnamyl)Cl]; sodium t-butanolate in 1,4-dioxane
Buchwald-Hartwig cross-coupling; 17 h; Reflux;
参考文献
Chartoire, Anthony; Lesieur, Mathieu; Slawin, Alexandra M. Z.; Nolan, Steven P.; Cazin, Catherine S. J.
Organometallics, 2011 , vol. 30, # 16 p. 4432 - 4436
反应条件
potassium hydroxide in dimethyl sulfoxide
T=130°C; 24 h; sealed tube;
参考文献
Fang, Yang; Zheng, Yueqin; Wang, Zhiyong
European Journal of Organic Chemistry, 2012 , # 8 p. 1495 - 1498
反应条件
potassium hexamethylsilazane in 1,4-dioxane
T=100°C; metal-free Buchwald-Hartwig amination; 0.5 h; Inert atmosphere;
参考文献
Bolliger, Jeanne L.; Frech, Christian M.
Tetrahedron, 2009 , vol. 65, # 6 p. 1180 - 1187
反应条件
potassium hexamethylsilazane in 1,4-dioxane
T=100°C; metal-free Buchwald-Hartwig amination; 0.5 h; Inert atmosphere;
参考文献
Bolliger, Jeanne L.; Frech, Christian M.
Tetrahedron, 2009 , vol. 65, # 6 p. 1180 - 1187
