3-(1-吡咯烷基)苯甲酸合成路线 （共 3 条）
反应条件
lithium hydroxide in 1,4-dioxane; water 1.) RT, 10 min, 2.) 40 deg C, 30 min;
参考文献
Semple, Graeme; Ryder, Hamish; Rooker, David P.; Batt, Andrzej R.; Kendrick, David A.; Szelke, Michael; Ohta, Mitsuaki; Satoh, Masato; Nishida, Akito; Akuzawa, Shinobu; Miyata, Keiji
Journal of Medicinal Chemistry, 1997 , vol. 40, # 3 p. 331 - 341
反应条件
1: 1.) NaH, 2.) KI / 1.) DMF, 0 deg C, 14 h, 2.) DMF, 80 deg C, 72 h 2: 80 percent / LiOH*H2O / dioxane; H2O / 1.) RT, 10 min, 2.) 40 deg C, 30 min View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 3 p. 331 - 341
反应条件
1: 88 percent / acetyl chloride / 1 h / Heating 2: 1.) NaH, 2.) KI / 1.) DMF, 0 deg C, 14 h, 2.) DMF, 80 deg C, 72 h 3: 80 percent / LiOH*H2O / dioxane; H2O / 1.) RT, 10 min, 2.) 40 deg C, 30 min View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 3 p. 331 - 341
