O,O′-二(三甲基甲硅烷基)胸苷合成路线 （共 89 条）
反应条件
1: 2.) hydrolyse
2: K2CO3 / dimethylformamide / 70 °C
View Scheme
参考文献
Decout; Lhomme
Tetrahedron Letters, 1981 , vol. 22, # 13 p. 1247 - 1250
反应条件
1: 2.) hydrolyse
2: K2CO3 / dimethylformamide / 70 °C
View Scheme
参考文献
Decout; Lhomme
Tetrahedron Letters, 1981 , vol. 22, # 13 p. 1247 - 1250
反应条件
1: 2.) hydrolyse
2: K2CO3 / dimethylformamide / 70 °C
View Scheme
参考文献
Decout; Lhomme
Tetrahedron Letters, 1981 , vol. 22, # 13 p. 1247 - 1250
反应条件
zinc(II) iodide in 1,2-dichloro-ethane
Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Wang; Chen; Tzeng
Nucleosides and Nucleotides, 1994 , vol. 13, # 5 p. 1201 - 1213
反应条件
isopropyl alcohol
1.) CH2Cl2, room temperature, 20 h, 2.) 1 h; Yield given. Multistep reaction;
参考文献
Novikov; Ozerov; Brel'; Solodunova; Ozerova
Chemistry of Heterocyclic Compounds, 1996 , vol. 32, # 3 p. 328 - 332
反应条件
ammonium sulfate; chlorosulphonyl isocyanate in acetonitrile
2 h; Heating;
参考文献
Ubasawa, Masaru; Takashima, Hideaki; Sekiya, Kouichi
Nucleosides and Nucleotides, 1998 , vol. 17, # 12 p. 2241 - 2247
反应条件
1.) acetonitrile, 0 degC, 2.) 0 degC to R.T. 2 h; Yield given. Multistep reaction;
参考文献
Robins; Hatfield
Canadian Journal of Chemistry, 1982 , vol. 60, # 5 p. 547 - 553
反应条件
1: 47 percent / CH2Cl2 / 72 h / Ambient temperature
2: 64 percent / 0.1 M HCl / 15 h / Heating
3: 45 percent / 1,5-diazabicyclo<4.3.0>non-5-ene (DBN) / dimethylformamide / 30 h / Heating
4: 74 percent / aq. M NaOH / dioxane / 6 h / Ambient temperature
View Scheme
参考文献
Phadtare, Shashikant; Zemlicka, Jiri
Journal of Organic Chemistry, 1989 , vol. 54, # 15 p. 3675 - 3679
反应条件
1: 98 percent / trimethylsilyl trifluoromethanesulfonate / CHCl3
2: NaOH; pyridine / methanol; H2O
View Scheme
参考文献
Kawashima, Etsuko; Umabe, Kaoru; Sekine, Takeshi
The Journal of organic chemistry, 2002 , vol. 67, # 15 p. 5142 - 5151
反应条件
tin(IV) chloride in 1,2-dichloro-ethane; acetonitrile
1.) -10 deg C, 75 min, 2.) room temp., 30 min;
参考文献
Feringa, Ben L.; Dannenberg, W.
Recueil: Journal of the Royal Netherlands Chemical Society, 1984 , vol. 103, # 6 p. 192 - 196
