1,3-二硝基-5-乙烯基-苯合成路线 （共 10 条）
反应条件
iodosylbenzene; FeCllt;(S)-Bitet(OMe)2gt;4TPP-eclipsed in dichloromethane 3 h; Title compound not separated from byproducts;
参考文献
Naruta, Yoshinori; Ishihara, Nobuo; Tani, Fumito; Maruyama, Kazuhiro
Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 1 p. 158 - 166
反应条件
1: vinyl-magnesium bromide With zinc(II) chloride in tetrahydrofuran
T=0 - 20°C; 1.16667 h;
2: 1-Iodo-3,5-dinitrobenzene With bis-triphenylphosphine-palladium(II) chloride; 2,6-di-tert-butyl-4-methyl-phenol in tetrahydrofuran
T=20°C; Negishi coupling; 18 h;
参考文献
Jian, Huahua; Tour, James M.
Journal of Organic Chemistry, 2005 , vol. 70, # 9 p. 3396 - 3424
参考文献
Nycomed Imaging AS
Patent: US6310243 B1, 2001 ;
Title/Abstract Full Text Show Details
Amersham Health AS
Patent: US6448442 B1, 2002 ;
参考文献
Nycomed Imaging AS
Patent: US5882628 A1, 1999 ;
反应条件
sodium acetate; palladium diacetate; tris-(o-tolyl)phosphine in N,N-dimethyl-formamide
T=90°C; Heck reaction; P=7600.51 Torr; 20 h; Inert atmosphereAutoclave;
参考文献
Nobre, Sabrina M.; Muniz, Mauro N.; Seferin, Marcus; Da Silva, Wagner M.; Monteiro, Adriano L.
Applied Organometallic Chemistry, 2011 , vol. 25, # 4 p. 289 - 293
反应条件
sodium acetate; palladium diacetate; tris-(o-tolyl)phosphine in N,N-dimethyl-formamide
T=90°C; Heck reaction; P=7600.51 Torr; 3 h; Inert atmosphereAutoclave;
参考文献
Nobre, Sabrina M.; Muniz, Mauro N.; Seferin, Marcus; Da Silva, Wagner M.; Monteiro, Adriano L.
Applied Organometallic Chemistry, 2011 , vol. 25, # 4 p. 289 - 293
反应条件
sodium acetate; palladium diacetate; tris-(o-tolyl)phosphine in N,N-dimethyl-formamide
T=90°C; Heck reaction; P=7600.51 Torr; 0.5 h; Inert atmosphereAutoclave;
参考文献
Nobre, Sabrina M.; Muniz, Mauro N.; Seferin, Marcus; Da Silva, Wagner M.; Monteiro, Adriano L.
Applied Organometallic Chemistry, 2011 , vol. 25, # 4 p. 289 - 293
反应条件
1.1: 85 percent / Br2; nitric acid; sulfuric acid / 2 h / 80 °C
2.1: 91 percent / CuI; NaI; N,N'-dimethylethylenediamine / dioxane / 31 h / 110 °C
3.1: ZnCl2 / tetrahydrofuran / 1.17 h / 0 - 20 °C
3.2: 89 percent / Pd(PPh3)2Cl2; BHT / tetrahydrofuran / 18 h / 20 °C
View Scheme
参考文献
Jian, Huahua; Tour, James M.
Journal of Organic Chemistry, 2005 , vol. 70, # 9 p. 3396 - 3424
反应条件
1.1: 91 percent / CuI; NaI; N,N'-dimethylethylenediamine / dioxane / 31 h / 110 °C
2.1: ZnCl2 / tetrahydrofuran / 1.17 h / 0 - 20 °C
2.2: 89 percent / Pd(PPh3)2Cl2; BHT / tetrahydrofuran / 18 h / 20 °C
View Scheme
参考文献
Jian, Huahua; Tour, James M.
Journal of Organic Chemistry, 2005 , vol. 70, # 9 p. 3396 - 3424
反应条件
sodium acetate; palladium diacetate; tris-(o-tolyl)phosphine in N,N-dimethyl-formamide
Heck reaction; P=3800.26 Torr; Inert atmosphereAutoclave;
参考文献
Nobre, Sabrina M.; Muniz, Mauro N.; Seferin, Marcus; Da Silva, Wagner M.; Monteiro, Adriano L.
Applied Organometallic Chemistry, 2011 , vol. 25, # 4 p. 289 - 293
