1: 3-bromo-pyridine With n-butyllithium in diethyl ether; hexane T=-78°C; 0.416667 h; 2: With zinc dibromide in diethyl ether; hexane T=-78 - 20°C; 3: 2-pyrimidinyl chloride With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran Heating; Further stages.;

tetrakis(triphenylphosphine) palladium(0); sodium carbonate in ethylene glycol dimethyl ether T=90°C; Suzuki coupling; 1 h;

palladium diacetate; tris-(o-tolyl)phosphine in toluene T=20°C; 5 h; Inert atmosphere;

potassium hydroxide; tetrabutylammomium bromide; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran 8 h; Heating;

iron (III) acetylacetonate in tetrahydrofuran T=-30°C; 0.166667 h;

1.1: n-BuLi / toluene; hexane; tetrahydrofuran / -50 °C 1.2: triisopropyl borate / toluene; tetrahydrofuran; hexane / -50 - -15 °C 1.3: 73 percent / aq. NaOH / toluene; tetrahydrofuran; hexane 2.1: 53 percent / Pd(PPh3)4; aq. Na2CO3 / 1,2-dimethoxy-ethane / 1 h / 90 °C View Scheme