3,5-二甲氧基苯甲醛合成路线 （共 226 条）
反应条件
1: 66 percent / acetic anhydride; Et3N / 5 h / 90 °C 2: quinoline; copper chromite / 1 h / 210 °C View Scheme
参考文献
Solladie, Guy; Pasturel-Jacope, Yacine; Maignan, Jean
Tetrahedron, 2003 , vol. 59, # 18 p. 3315 - 3321
反应条件
1: acetic anhydride; triethylamine / 6 h / 110 °C 2: quinoline; copper / 3 h / 200 °C / Inert atmosphere View Scheme
参考文献
Xiao, Chun-Fen; Zou, Yong; Du, Jian-Li; Sun, Hong-Yi; Liu, Xian-Ke
Synthetic Communications, 2012 , vol. 42, # 9 p. 1243 - 1258
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in methanol T=20°C; P=760.051 Torr; 2 h;
参考文献
Xing, Lixin; Wang, Xinyan; Cheng, Chuanjie; Zhu, Rui; Liu, Bo; Hu, Yuefei
Tetrahedron, 2007 , vol. 63, # 38 p. 9382 - 9386
反应条件
hydrogen; palladium on activated charcoal in methanol P=760 Torr; 18 h;
参考文献
Boyer, Francois-Didier; Ducrot, Paul-Henri
Tetrahedron Letters, 2005 , vol. 46, # 31 p. 5177 - 5180
反应条件
1.1: NaOMe; tetrabutylammonium iodide / dimethylformamide / 1 h / 20 °C 1.2: 60.7 percent / dimethylformamide / 8 h / 40 °C 2.1: 90 percent / BBr3 / CH2Cl2 / 2 h / 20 °C View Scheme
参考文献
Ali; Kondo; Tsuda
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 5 p. 1130 - 1136
反应条件
1: With triphenylphosphine in dichloromethane T=0 - 20°C; Ramirez-Corey-Fuchs reaction; 0.5 h; 2: With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene T=-78°C; Ramirez-Corey-Fuchs reaction; 2 h; 3: With ammonium chloride in tetrahydrofuran; n-heptane; ethylbenzene Ramirez-Corey-Fuchs reaction;
参考文献
Xia, Yan; Jin, Yinglan; Kaur, Navneet; Choi, Yongseok; Lee, Kyeong
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 6 p. 2386 - 2396
反应条件
1: triphenylphosphine / dichloromethane / 0.5 h / 0 - 20 °C 2: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 2 h / -78 °C View Scheme
参考文献
Xia, Yan; Jin, Yinglan; Kaur, Navneet; Choi, Yongseok; Lee, Kyeong
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 6 p. 2386 - 2396
反应条件
1: With piperidine; pyridine T=100°C; 6 h; 2: in water pH=3;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2007/71348 A1, 2007 ;
Location in patent: Page/Page column 87 ;
反应条件
hydrogenchloride; malonic acid in pyridine
参考文献
AstraZeneca UK Limited
Patent: US6251910 B1, 2001 ;
US 6251910 B1
反应条件
potassium acetate; sodium carbonate 1.) 160 deg C, 1 h; 170-180 deg C, 3 h, 2.) 3 h; Yield given. Multistep reaction;
参考文献
Jamie, Joanne F.; Rickards, Rodney W.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 24 p. 3613 - 3621
