4-甲氧基-4-连苯基羧酸乙酯合成路线 （共 49 条）
反应条件
1: 94 percent / pyridine / 12 h / 20 °C 2: 94 percent / Pd(dba)2; 2-dicyclohexylphosphinobiphenyl; TBAF / tetrahydrofuran / 6 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 4 p. 1137 - 1143
反应条件
copper(l) iodide; potassium carbonate; tris-(o-tolyl)phosphine; palladium dichloride in N,N-dimethyl-formamide T=80°C; Hiyama coupling; 15 h;
参考文献
Tetrahedron Letters, , vol. 52, # 52 p. 7178 - 7181
反应条件
bis(η3-allyl-μ-chloropalladium(II)); P(C6H4)CH(C(CH3)C(Si(CH3)3))2 in tetrahydrofuran; acetonitrile T=20°C; Negishi coupling reaction; 48 h;
参考文献
Ribagnac, Philippe; Blug, Matthias; Villa-Uribe, Jose; Le Goff, Xavier-Frederic; Gosmini, Corinne; Mezailles, Nicolas
Chemistry - A European Journal, 2011 , vol. 17, # 51 p. 14389 - 14393
反应条件
1.1: s-BuLi / diethyl ether; hexane / 1.5 h / -75 - 20 °C 1.2: diethyl ether; hexane / 1.5 h / -75 - 20 °C 2.1: KHF2 / diethyl ether; H2O; hexane / 20 °C 3.1: HBF4; NaNO2 / H2O / 0.5 h / 0 - 5 °C 3.2: 93 percent / Pd(OAc)2 / dioxane / 2 h / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 8 p. 1875 - 1883
反应条件
1.1: KHF2 / diethyl ether; H2O; hexane / 20 °C 2.1: HBF4; NaNO2 / H2O / 0.5 h / 0 - 5 °C 2.2: 93 percent / Pd(OAc)2 / dioxane / 2 h / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 8 p. 1875 - 1883
反应条件
1: N,N-dimethyl-formamide / 20 °C / |Inert atmosphere; |Schlenk technique 2: C27H22Cl2N3NiP / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 12 h / |Inert atmosphere; |Schlenk technique; |Heating View Scheme
参考文献
Dalton Transactions, , vol. 41, # 34 p. 10453 - 10464,12
反应条件
1: 16 h / 110 °C 2: lithium chloride / tetrahydrofuran; toluene / 24 h / 110 °C / |Schlenk technique; |Inert atmosphere View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 53, # 2 p. 521 - 525
Angew. Chem., , vol. 126, # 2 p. 531 - 535,5
反应条件
hydrogenchloride Combinatorial reaction / High throughput screening (HTS); Product distribution / selectivity;
参考文献
US2007/43234 A1, ;
Page/Page column 51-52 ;
反应条件
sodium hydroxide in tetrahydrofuran
参考文献
Wyeth
Patent: US2003/18024 A1, 2003 ;
