2-氧代-2-(3-吡啶)乙酸乙酯合成路线 （共 9 条）
反应条件
hydrogenchloride; sodium chloride; sodium hydrogencarbonate in diethyl ether
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6251926 B1, 2001 ;
反应条件
1: 3-bromo-pyridine With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; Inert atmosphere; 2: oxalic acid diethyl ester in tetrahydrofuran; hexane T=0 - 20°C; 20 h; Inert atmosphere;
参考文献
Thai, Karen; Langdon, Steven M.; Bilodeau, Francois; Gravel, Michel
Organic Letters, 2013 , vol. 15, # 9 p. 2214 - 2217
反应条件
selenium(IV) oxide 16 h; Reflux;
参考文献
WO2010/8775 A1, ;
Page/Page column 31-32 ;
WO 2010/008775 A1
反应条件
1: CHCl3 / 1 h / 20 °C 2: CHCl3 3: NEtPr2-i / CHCl3 / 1 h / 0 °C 4: ZnCl2 / acetonitrile / 5 h / 20 °C 5: 467 mg / acetonitrile; ethanol / 15 h / Heating View Scheme
参考文献
Chemistry of Heterocyclic Compounds, , vol. 40, # 6 p. 759 - 766
反应条件
1: ZnCl2 / acetonitrile / 5 h / 20 °C 2: 467 mg / acetonitrile; ethanol / 15 h / Heating View Scheme
参考文献
Chemistry of Heterocyclic Compounds, , vol. 40, # 6 p. 759 - 766
反应条件
1: CHCl3 2: NEtPr2-i / CHCl3 / 1 h / 0 °C 3: ZnCl2 / acetonitrile / 5 h / 20 °C 4: 467 mg / acetonitrile; ethanol / 15 h / Heating View Scheme
参考文献
Chemistry of Heterocyclic Compounds, , vol. 40, # 6 p. 759 - 766
反应条件
1: NEtPr2-i / CHCl3 / 1 h / 0 °C 2: ZnCl2 / acetonitrile / 5 h / 20 °C 3: 467 mg / acetonitrile; ethanol / 15 h / Heating View Scheme
参考文献
Chemistry of Heterocyclic Compounds, , vol. 40, # 6 p. 759 - 766
反应条件
hydrogenchloride 8 h; Heating;
参考文献
Nurullaeva, M. K.; Azizov, U. M.; Mikhlina, E. E.; Turchin, K. F.; Silin, V. A.; Yakhontov, L. N.
Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 5 p. 340 - 344
Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 5 p. 563 - 567
参考文献
Journal of Chemical Research, Miniprint, , # 10 p. 2422 - 2434
