3-(二乙氧基甲基)异噻唑合成路线 （共 12 条）
反应条件
hydrogenchloride in acetone 0.75 h; Heating;
参考文献
Inami; Shiba
Bulletin of the Chemical Society of Japan, 1985 , vol. 58, # 1 p. 352 - 360
反应条件
1: hydrogenchloride / water; acetone / 1 h / Reflux 2: tetrahydrofuran; toluene / 12 h / 0 °C 3: Dess-Martin periodane / dichloromethane / 2 h / 20 °C / Inert atmosphere View Scheme
参考文献
Fache; Cros; Piva; Lefebvre
Synthetic Communications, 2012 , vol. 42, # 14 p. 2098 - 2109
反应条件
1: in ethanol
0.75 h; Molecular sieveHeating / reflux;
2: With water; sodium hydrogencarbonate in ethyl acetate
参考文献
UNIVERSITY OF STRATHCLYDE
Patent: WO2008/38018 A1, 2008 ;
Location in patent: Page/Page column 64-65 ;
反应条件
3 A molecular sieve in ethanol
0.5 h; Heating;
参考文献
Merritt, Eleanor A.; Bagley, Mark C.
Synlett, 2007 , # 6 p. 954 - 958
反应条件
trichloromonobromomethane; 1,8-diazabicyclo[5.4.0]undec-7-ene in dichloromethane
T=0°C; 1.16667 h;
参考文献
Fache; Cros; Piva; Lefebvre
Synthetic Communications, 2012 , vol. 42, # 14 p. 2098 - 2109
反应条件
1: 23 percent / phosphorus pentasulfide / CH2Cl2 / 2 h / 0 °C
2: 58 percent / ethanol / 1 h / Heating
View Scheme
参考文献
Bagley, Mark C.; Xiong, Xin
Organic Letters, 2004 , vol. 6, # 19 p. 3401 - 3404
反应条件
1: 100 percent / ammonium sulfide / methanol / 24 h / 20 °C
2: 100 percent / 4 Angstroem MS / ethanol / 1 h / Heating
View Scheme
参考文献
Merritt, Eleanor A.; Bagley, Mark C.
Synlett, 2007 , # 6 p. 954 - 958
反应条件
1: 55 percent / NH4OH, NH4Cl / H2O
2: 64 percent / P2S5 / benzene / Ambient temperature
3: 89 percent / 4 Angstroems molecular sieves / ethanol
View Scheme
参考文献
Toogood, Peter L.; Hollenbeck, Jessica J.; Lam, Huong M.; Li, Li
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 13 p. 1543 - 1546
反应条件
1: 12-molybdophosphoric acid HPMo / ethanol / 3 h / 120 °C / Microwave irradiation
2: trichloromonobromomethane; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.17 h / 0 °C
View Scheme
参考文献
Fache; Cros; Piva; Lefebvre
Synthetic Communications, 2012 , vol. 42, # 14 p. 2098 - 2109
反应条件
1: 96 percent / PTSA / methanol / 24 h / Heating
2: 86 percent / aq. HCl / acetone / 2 h / Heating
View Scheme
参考文献
Peltier, Hillary M.; McMahon, Jeffrey P.; Patterson, Andrew W.; Ellman, Jonathan A.
Journal of the American Chemical Society, 2006 , vol. 128, # 50 p. 16018 - 16019
