反应条件
1: 4-hydroxy-piperidine With malonic acid di(tert-butyl)-ester in acetonitrile 20 h; 2: methyl iodide With sodium hydride in acetonitrile; mineral oil T=0 - 25°C; 20.5 h; 3: With hydrogenchloride in 1,4-dioxane T=25°C; 20 h;
参考文献
GLAXOSMITHKLINE LLC; HAMMOND, Marlys; KALLANDER, Lara, S.; LAWHORN, Brian, Griffin; PHILP, Joanne; SARPONG, Martha, A.; SEEFELD, Mark, Andrew
Patent: WO2011/149827 A1, 2011 ;
Location in patent: Page/Page column 149-150 ;