1: 4-nitropyrazole With sodium hydride in N,N-dimethyl-formamide; mineral oil T=-25°C; 0.5 h; 2: ethyl bromide in N,N-dimethyl-formamide; mineral oil T=-25°C; 6 h;
参考文献
GENENTECH, INC.; Crawford, James John; Ortwine, Daniel Fred; Wei, BinQing; Young, Wendy B.
Patent: US2013/116246 A1, 2013 ;
Location in patent: Paragraph 0354; 0355 ;
1: ethyl bromide With magnesium in tetrahydrofuran Inert atmosphere; 2: 4-cyanotoluene With copper(l) iodide in tetrahydrofuran T=20°C; 10 h; Inert atmosphere; 3: With hydrogenchloride; water in tetrahydrofuran T=0 - 20°C;
参考文献
Ueno, Satoshi; Shimizu, Ryosuke; Kuwano, Ryoichi
Angewandte Chemie, International Edition, 2009 , vol. 48, p. 4543 - 4545
Angewandte Chemie, 2009 , vol. 121, p. 4613 - 4615
