叔丁基肼盐酸盐合成路线

参考文献

WO2010/111418 A2, ;

Page/Page column 100 ;

参考文献

KUMIAI CHEMICAL INDUSTRY CO., LTD.; IHARA CHEMICAL INDUSTRY CO., LTD.
Patent: EP1364946 A1, 2003 ;
Location in patent: Page/Page column 193 ;

1246078-79-4+

7400-27-3叔丁基肼盐酸盐

1246078-80-71-(叔丁基)-5-(2,4,5-三氟苯基)-1H-吡唑

参考文献

WO2010/111418 A2, ;

Page/Page column 121 ;

7400-27-3叔丁基肼盐酸盐+

920-37-62-氯丙烯腈

1152980-49-83-氨基-1-叔丁基吡唑+

442850-71-71-叔丁基-1H-吡唑-5-胺

参考文献

Ji, Nan; Meredith, Erik; Liu, Donglei; Adams, Christopher M.; Artman III, Gerald D.; Jendza, Keith C.; Ma, Fupeng; Mainolfi, Nello; Powers, James J.; Zhang, Chun
Tetrahedron Letters, 2010 , vol. 51, # 52 p. 6799 - 6801

7400-27-3叔丁基肼盐酸盐+

108-94-1环己酮

37426-22-5N-(环己亚基氨基)-2-甲基丙烷-2-胺

参考文献

Baldwin, Jack E.; Adlington, Robert M.; Bottaro, Jeffrey C.; Kolhe, Jayant N.; Perry, Matthew W. D.; Jain, Ashok U.
Tetrahedron, 1986 , vol. 42, # 15 p. 4223 - 4234

7400-27-3叔丁基肼盐酸盐+

94-05-32-氰基-3-乙氧基丙烯酸乙酯

112779-14-35-氨基-1-叔丁基吡唑-4-甲酸乙酯

参考文献

Anderson, Kevin William; Fotouhi, Nader; Gillespie, Paul; Goodnow, Robert Alan; Guertin, Kevin Richard; Haynes, Nancy-Ellen; Myers, Michael Paul; Pietranico-Cole, Sherrie Lynn; Qi, Lida; Rossman, Pamela Loreen; Scott, Nathan Robert; Thakkar, Kshitij Chhabilbhai; Tilley, Jefferson Wright; Zhang, Qiang
Patent: US2007/225280 A1, 2007 ;
Location in patent: Page/Page column 19 ;
US 20070225280 A1

7400-27-3叔丁基肼盐酸盐+

72459-84-8

112779-14-35-氨基-1-叔丁基吡唑-4-甲酸乙酯

参考文献

Beck, James R.; Lynch, Michael P.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 693 - 695

7400-27-3叔丁基肼盐酸盐+

541-41-3氯甲酸乙酯

64739-41-9

参考文献

Cavill, Julie L.; Elliott, Richard L.; Evans, Gareth; Jones, Ian L.; Platts, James A.; Ruda, Antonio M.; Tomkinson, Nicholas C. O.
Tetrahedron, 2006 , vol. 62, # 2-3 p. 410 - 421

503471-30-53-甲酰基-4-氧代丁酸乙酯+

7400-27-3叔丁基肼盐酸盐

682757-49-91-叔丁基-1H -吡唑- 3 -羧酸乙酯

参考文献

ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2007/71963 A2, 2007 ;
Location in patent: Page/Page column 58 ;
WO 2007/071963 A2

59997-51-2新戊酰基乙腈+

7400-27-3叔丁基肼盐酸盐

787552-38-9

参考文献

Suijkerbuijk, Bart M.J.M.; Niculescu-Duvaz, Ion; Gaulon, Catherine; Dijkstra, Harmen P.; Niculescu-Duvaz, Dan; Menard, Delphine; Zambon, Alfonso; Nourry, Arnaud; Davies, Lawrence; Manne, Helen A.; Friedlos, Frank; Ogilvie, Lesley M.; Hedley, Douglas; Lopes, Filipa; Preece, Natasha P.U.; Moreno-Farre, Javier; Raynaud, Florence I.; Kirk, Ruth; Whittaker, Steven; Marais, Richard; Springer, Caroline J.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 7 p. 2741 - 2756