7-(4-乙酰基哌嗪-1-基)-1-乙基-6-氟-4-氧代-1,4-二氢喹啉-3-羧酸合成路线 （共 9 条）
反应条件
triethylamine
T=90 - 100°C;
参考文献
Koga, Hiroshi; Itoh, Akira; Murayama, Satoshi; Suzue, Seigo; Irikura, Tsutomu
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1358 - 1363
反应条件
in water; acetic acid
参考文献
Kyorin Seiyaku Kabushiki Kaisha
Patent: US4448962 A1, 1984 ;
反应条件
1: 100 percent / 2 h / 120 - 130 °C
2: diphenyl ether / 1 h / Heating
3: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C
4: 90 percent / 2N NaOH / 2 h / Heating
5: 66 percent / 5 h / 130 - 140 °C
6: 97 percent / Et3N / 90 - 100 °C
View Scheme
参考文献
Koga, Hiroshi; Itoh, Akira; Murayama, Satoshi; Suzue, Seigo; Irikura, Tsutomu
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1358 - 1363
反应条件
1: diphenyl ether / 1 h / Heating
2: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C
3: 90 percent / 2N NaOH / 2 h / Heating
4: 66 percent / 5 h / 130 - 140 °C
5: 97 percent / Et3N / 90 - 100 °C
View Scheme
参考文献
Koga, Hiroshi; Itoh, Akira; Murayama, Satoshi; Suzue, Seigo; Irikura, Tsutomu
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1358 - 1363
反应条件
1: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C
2: 90 percent / 2N NaOH / 2 h / Heating
3: 66 percent / 5 h / 130 - 140 °C
4: 97 percent / Et3N / 90 - 100 °C
View Scheme
参考文献
Koga, Hiroshi; Itoh, Akira; Murayama, Satoshi; Suzue, Seigo; Irikura, Tsutomu
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1358 - 1363
反应条件
1: K2CO3 / dimethylformamide / 2 h / 60 - 90 °C
2: 2N NaOH / 2 h / Heating
3: 97 percent / Et3N / 90 - 100 °C
View Scheme
参考文献
Koga, Hiroshi; Itoh, Akira; Murayama, Satoshi; Suzue, Seigo; Irikura, Tsutomu
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1358 - 1363
反应条件
1: 66 percent / 5 h / 130 - 140 °C
2: 97 percent / Et3N / 90 - 100 °C
View Scheme
参考文献
Koga, Hiroshi; Itoh, Akira; Murayama, Satoshi; Suzue, Seigo; Irikura, Tsutomu
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1358 - 1363
反应条件
1: 90 percent / 2N NaOH / 2 h / Heating
2: 66 percent / 5 h / 130 - 140 °C
3: 97 percent / Et3N / 90 - 100 °C
View Scheme
参考文献
Koga, Hiroshi; Itoh, Akira; Murayama, Satoshi; Suzue, Seigo; Irikura, Tsutomu
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1358 - 1363
反应条件
1: 2N NaOH / 2 h / Heating
2: 97 percent / Et3N / 90 - 100 °C
View Scheme
参考文献
Koga, Hiroshi; Itoh, Akira; Murayama, Satoshi; Suzue, Seigo; Irikura, Tsutomu
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1358 - 1363
