3-硝基-4-乙酰氨基苯酚合成路线 （共 15 条）
参考文献
Syntex (U.S.A.) Inc.
Patent: US4072696 A1, 1978 ;
反应条件
1.1: BF3/MeOH / methanol / 5 h / |Inert atmosphere; |Reflux 1.2: 0.33 h / -15 - 0 °C 2.1: sodium acetate; palladium diacetate / methanol / 12 h / 20 °C 3.1: carbon; hydrogen / methanol / 24 h / 750.08 Torr View Scheme
参考文献
ZYLUM BETEILIGUNGSGESELLSCHAFT MBH and CO. PATENTE II KG; Boege, Nicolas; Kreipl, Andreas; Schmidt, Bernd; Hoelter, Frank; Berger, René
Patent: US2013/53598 A1, 2013 ;
反应条件
bromine; acetic acid
参考文献
Heller et al.
Journal fuer Praktische Chemie (Leipzig), 1931 , vol. <2> 129, p. 211,229
参考文献
Heller et al.
Journal fuer Praktische Chemie (Leipzig), 1931 , vol. <2> 129, p. 211,229
参考文献
Heller et al.
Journal fuer Praktische Chemie (Leipzig), 1931 , vol. <2> 129, p. 211,229
反应条件
sodium carbonate; potassium iodide in N,N-dimethyl-formamide T=50°C; 24 h;
参考文献
Rivara, Mirko; Zuliani, Valentina; Cocconcelli, Giuseppe; Morini, Giovanni; Comini, Mara; Rivara, Silvia; Mor, Marco; Bordi, Fabrizio; Barocelli, Elisabetta; Ballabeni, Vigilio; Bertoni, Simona; Plazzi, Pier Vincenzo
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 5 p. 1413 - 1424
反应条件
sodium hydrogencarbonate in methanol
2 h; Inert atmosphere;
参考文献
Schmidt, Bernd; Hoelter, Frank; Berger, Rene; Jessel, Soenke
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 14-15 p. 2463 - 2473
反应条件
MOA; water; nitric acid in chloroform
Nitration; 6 h; Heating;
参考文献
Sana, Sariah; Rajanna; Ali, Mir Moazzam; Saiprakash
Chemistry Letters, 2000 , # 1 p. 48 - 49
反应条件
1: 87 percent / fumig nitric acid (87percent) / 1.5 h / 18 °C
2: 91 percent / K2CO3 / methanol / 0.5 h / 0 °C
View Scheme
参考文献
Han, Gyoonhee; Shin, Kye Jung; Kim, Dong Chan; Yoo, Kyung Ho; Kim, Dong Jin; Park, Sang Woo
Heterocycles, 1996 , vol. 43, # 11 p. 2495 - 2502
参考文献
Matsuno, Takanobu; Matsukawa, Tomoko; Sakuma, Yoshiharu; Kunieda, Takehisa
Chemical & Pharmaceutical Bulletin, 1989 , vol. 37, # 5 p. 1422 - 1423
