(S)-(-)-1,2,3,4-四氢异喹啉-3-羧酸合成路线 （共 45 条）
反应条件
sulfuric acid in 1,4-dioxane 17 h; Ambient temperature;
参考文献
Klutchko; Blankley; Fleming; Hinkley; Werner; Nordin; Holmes; Hoefle; Cohen; Essenburg
Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 1953 - 1961
反应条件
potassium permanganate in N,N-dimethyl-formamide T=0 - 20°C; 100.5 h; Inert atmosphere;
参考文献
Zheng, Meiqing; Yang, Yifan; Zhao, Ming; Zhang, Xiaoyi; Wu, Jianhui; Chen, Gong; Peng, Li; Wang, Yuji; Peng, Shiqi
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 5 p. 1672 - 1681
反应条件
1: H2SO4 / dioxane / 17 h / Ambient temperature 2: 78 percent / Et3N, DCC, 1-hydroxybenzotriazole / tetrahydrofuran / Ambient temperature 3: TFA / 1 h / Ambient temperature 4: 80 percent / AcOH / toluene / 0.5 h / 95 °C View Scheme
参考文献
Klutchko; Blankley; Fleming; Hinkley; Werner; Nordin; Holmes; Hoefle; Cohen; Essenburg
Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 1953 - 1961
反应条件
(+/-)-camphor-10-sulfonic acid; acetic acid T=120°C; other carboxylic acid; Rate constant;
参考文献
Shiraiwa, Tadashi; Furukawa, Tsuyoshi; Tsuchida, Tamotsu; Sakata, Shinji; Sunami, Michio; Kurokawa, Hidemoto
Bulletin of the Chemical Society of Japan, 1991 , vol. 64, # 12 p. 3729 - 3731
反应条件
1: COCl2 View Scheme
参考文献
Goehring, Wolfgang; Gokhale, Surendra; Hilpert, Hans; Roessler, Felix; Schlageter, Markus; Vogt, Peter
Chimia, 1996 , vol. 50, # 11 p. 532 - 537
反应条件
sodium hydroxide in 1,4-dioxane T=20°C; 12 h;
参考文献
Charton, Julie; Gassiot, Amaury Cazenave; Melnyk, Patricia; Girault-Mizzi, Sophie; Sergheraert, Christian
Tetrahedron Letters, 2004 , vol. 45, # 38 p. 7081 - 7085
反应条件
triethylamine in N,N-dimethyl-formamide T=20°C; pH=10; 48 h;
参考文献
Liu, Jiawang; Cui, Guohui; Zhao, Ming; Cui, Chunying; Ju, Jingfang; Peng, Shiqi
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 24 p. 7773 - 7788
反应条件
1: COCl2 3: 85 percent / H2 / Rh/Alox / ethyl acetate / 150 °C / 112509 Torr View Scheme
参考文献
Goehring, Wolfgang; Gokhale, Surendra; Hilpert, Hans; Roessler, Felix; Schlageter, Markus; Vogt, Peter
Chimia, 1996 , vol. 50, # 11 p. 532 - 537
反应条件
1: COCl2 3: 85 percent / H2 / Rh/Alox / ethyl acetate / 150 °C / 112509 Torr 4: dimethylformamide / 120 °C 5: 1.) MeNH2, 2.) HCl View Scheme
参考文献
Goehring, Wolfgang; Gokhale, Surendra; Hilpert, Hans; Roessler, Felix; Schlageter, Markus; Vogt, Peter
Chimia, 1996 , vol. 50, # 11 p. 532 - 537
反应条件
1: COCl2 3: 85 percent / H2 / Rh/Alox / ethyl acetate / 150 °C / 112509 Torr 4: dimethylformamide / 120 °C 5: 1.) MeNH2, 2.) HCl 7: H2 / Pd/C View Scheme
参考文献
Goehring, Wolfgang; Gokhale, Surendra; Hilpert, Hans; Roessler, Felix; Schlageter, Markus; Vogt, Peter
Chimia, 1996 , vol. 50, # 11 p. 532 - 537
