boron trifluoride diethyl etherate in dichloromethane T=-25°C; 2 h; Inert atmosphere;

1.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C 2.1: boron trifluoride diethyl etherate / m-xylene / -78 - 20 °C 2.2: 17 h / 190 °C / |Autoclave 3.1: hydrogenchloride; sodium nitrite / water / 0.17 h / 0 - 5 °C 3.2: 1 h / 20 °C 4.1: 2-methyl-2-iodopropane / dichloromethane / 18 h / 20 °C / |Inert atmosphere View Scheme

1.1: boron trifluoride diethyl etherate / m-xylene / -78 - 20 °C 1.2: 17 h / 190 °C / |Autoclave 2.1: hydrogenchloride; sodium nitrite / water / 0.17 h / 0 - 5 °C 2.2: 1 h / 20 °C 3.1: 2-methyl-2-iodopropane / dichloromethane / 18 h / 20 °C / |Inert atmosphere View Scheme

1.1: hydrogenchloride; sodium nitrite / water / 0.17 h / 0 - 5 °C 1.2: 1 h / 20 °C 2.1: 2-methyl-2-iodopropane / dichloromethane / 18 h / 20 °C / |Inert atmosphere View Scheme

hydrogenchloride; sodium nitrite

1: zinc chloride / 140 °C 2: 18 percent / HCl, NaNO2 View Scheme

palladium diacetate; triethylamine; triphenylphosphine in N,N-dimethyl-formamide T=80°C; intramolecular Heck olefination; 16 h;