2-(4-甲氧基苯基)丙-2-醇合成路线 （共 43 条）
反应条件
(i) KHSO4, (heating), (ii) H2, Pd-C, AcOEt; Multistep reaction;
参考文献
Jacquesy,R.; Patoiseau,J.-F.
Bulletin de la Societe Chimique de France, 1978 , vol. <II>, p. 255 - 262
反应条件
sulfuric acid; dihydrogen peroxide in benzene T=40°C;
参考文献
Zawadiak, Jan; Jakubowski, Bartlomiej; Stec, Zbigniew
International Journal of Chemical Kinetics, 2005 , vol. 37, # 1 p. 10 - 16
反应条件
sodium perborate; boron trifluoride diethyl etherate in tetrahydrofuran T=0°C; 1.5 h;
参考文献
Kabalka; Reddy; Narayana
Tetrahedron Letters, 1993 , vol. 34, # 48 p. 7667 - 7668
反应条件
1: With ammonia; lithium; tert-butyl alcohol in tetrahydrofuran T=-30°C; Birch Reduction; Inert atmosphere; 2: With water; ammonium chloride in tetrahydrofuran T=-20°C; Product distribution / selectivity;
参考文献
DALTON CHEMICAL LABORATORIES INC.; MIKAYLO, Valeriy; PARAMANANTHAM, Subakar; AVRUTOV, Ilya; BROWN, Martyn, A.; LI, Zemin; LAZAROWYCH, Natalie
Patent: WO2010/22520 A1, 2010 ;
Location in patent: Page/Page column 10-11 ;
参考文献
Birch
Journal and Proceedings of the Royal Society of New South Wales, 1949 , vol. 83, p. 245,248
反应条件
dichloromethane extract derived from 6percent aqueous hypochlorite/tetra-n-butylammonium bisulfate solution with pH value to 8-9 in dichloromethane T=20°C;
参考文献
Carrillo, Hector V.; Rodriguez, Angelica Y.; Landolt, Robert G.; Hendrickson, William H.
Synlett, 2011 , # 14 art. no. S03711ST, p. 2069 - 2071
反应条件
9,10-anthracenedicarbonitrile; oxygen in acetonitrile T=5 - 10°C; 0.333333 h; Photolysis; Product distribution; Further Variations:Reagents;
参考文献
Lykakis, Ioannis N.; Tanielian, Charles; Orfanopoulos, Michael
Organic Letters, 2003 , vol. 5, # 16 p. 2875 - 2878
反应条件
1: KHSO4, benzene-1,2-diol, picric acid / 220 °C
2: (i) NaBH4, BF3-Et2O, (EtOCH2CH2)2O, (ii) aq. NaOH, aq. H2O2
View Scheme
参考文献
Serra, Stefano
Tetrahedron Asymmetry, 2011 , vol. 22, # 6 p. 619 - 628
反应条件
1: 60 percent / TiCl3, LiAlH4 / 1,2-dimethoxy-ethane / 16 h / Heating
2: 1.) BBr3, 2.) 2N NaOH / 1.) CH2Cl2, RT, 4 h, 2.) CH2Cl2, MeOH
View Scheme
参考文献
Hartmann, Rolf W.; Kranzfelder, Gerhard; Angerer, Erwin, v.; Schoenenberger, Helmut
Journal of Medicinal Chemistry, 1980 , vol. 23, # 8 p. 841 - 848
反应条件
toluene-4-sulfonic acid
1 h; Ambient temperature;
参考文献
Richard, John P.; Jagannadham, Vandannapu; Amyes, Tina L.; Mishima, Masaaki; Tsuno, Yuho
Journal of the American Chemical Society, 1994 , vol. 116, # 15 p. 6706 - 6712
