1: 1.) LDA, 3.) Cu(OAc)2 2: 70 percent / pyridinium chlorochromate 3: 70 percent / 2M NaOH, Bu4NHSO4 / hexane; H2O / 24 h / Ambient temperature 4: 70 percent / O3 / CH2Cl2 / -78 °C 5: 1.) n-BuLi / 1.) THF-hexane, RT, 1 h, 2.) THF, -10 deg C, 1.5 h View Scheme

1: ozone, methyl sulphide / CH2Cl2 / Ambient temperature 2: 2.5 M methanolic NaOH / CH2Cl2 / -78 °C View Scheme

1: 1.) LiNEt2 / 1.) HMPT, benzene, THF, -10 deg C, 1.5 h, 2.) room temp., 2 h 2: 1.) O3, 2.) H2 / 2.) Lindlar catalyst / 1.) EtOAc, -60 deg C, 2.) 1 atm 3: 89 percent / 1percent aq. NaOH / diethyl ether / 72 h / Ambient temperature View Scheme

sodium perborate; sodium hydroxide; potassium dihydrogenphosphate; water in tert-butyl alcohol T=60°C; 24 h;

1: 1.) LDA, 3.) Cu(OAc)2 2: 70 percent / pyridinium chlorochromate 3: 70 percent / 2M NaOH, Bu4NHSO4 / hexane; H2O / 24 h / Ambient temperature 4: 70 percent / O3 / CH2Cl2 / -78 °C View Scheme

1: 1.) LDA, 3.) Cu(OAc)2 2: 70 percent / pyridinium chlorochromate 3: 70 percent / 2M NaOH, Bu4NHSO4 / hexane; H2O / 24 h / Ambient temperature View Scheme

dimethylsulfide; ozone in dichloromethane Ambient temperature;