2-叔丁基-4H-吡喃-4-酮合成路线 （共 5 条）
反应条件
trifluoroacetic acid in benzene
Ambient temperature12-18 h;
参考文献
Koreeda, Masato; Akagi, Hiroshi
Tetrahedron Letters, 1980 , vol. 21, p. 1197 - 1200
反应条件
1: 1.) lithium bis(trimethylsilyl)amide / 1.) THF, -78 deg C, 30 min, 2.) gradually warmed to room temp., 2-3 h, room temp.
2: 80 percent / trifluoroacetic acid / benzene / Ambient temperature; 12-18 h
View Scheme
参考文献
Koreeda, Masato; Akagi, Hiroshi
Tetrahedron Letters, 1980 , vol. 21, p. 1197 - 1200
反应条件
1: trans-4-methoxy-3-buten-2-one With lithium hexamethyldisilazane in tetrahydrofuran
T=-78°C; 1 h;
2: pivaloyl chloride in tetrahydrofuran
T=-78 - 20°C; 2.5 h;
3: With trifluoroacetic acid in toluene
T=-10 - 20°C;
参考文献
Furet, Pascal; Guagnano, Vito; Fairhurst, Robin A.; Imbach-Weese, Patricia; Bruce, Ian; Knapp, Mark; Fritsch, Christine; Blasco, Francesca; Blanz, Joachim; Aichholz, Reiner; Hamon, Jacques; Fabbro, Doriano; Caravatti, Giorgio
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 13 p. 3741 - 3748
反应条件
1.1: oxalyl dichloride / chloroform / 4 h / |Reflux
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C
2.2: 2.5 h / -78 - 20 °C
2.3: -10 - 20 °C
View Scheme
参考文献
Furet, Pascal; Guagnano, Vito; Fairhurst, Robin A.; Imbach-Weese, Patricia; Bruce, Ian; Knapp, Mark; Fritsch, Christine; Blasco, Francesca; Blanz, Joachim; Aichholz, Reiner; Hamon, Jacques; Fabbro, Doriano; Caravatti, Giorgio
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 13 p. 3741 - 3748
反应条件
1: ammonium hydroxide / water / 1 h / Reflux
2: phosphorus oxytribromide / 0.25 h / 120 °C
View Scheme
参考文献
Furet, Pascal; Guagnano, Vito; Fairhurst, Robin A.; Imbach-Weese, Patricia; Bruce, Ian; Knapp, Mark; Fritsch, Christine; Blasco, Francesca; Blanz, Joachim; Aichholz, Reiner; Hamon, Jacques; Fabbro, Doriano; Caravatti, Giorgio
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 13 p. 3741 - 3748
