N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=75°C; 9 - 13 h;

ammonium hydroxide; sodium disulfite T=140°C; 96 h;

trifluoroacetic acid in dichloromethane T=0 - 20°C; 3 h;

carbon disulfide; aluminium trichloride Erhitzen des Reaktionsprodukts mit wss. Salzsaeure;

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere 2.1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere 2.2: 0 °C / Inert atmosphere 3.1: copper(l) iodide; potassium carbonate; N-methyl-2-(methylamino)ethylamine / toluene / 24 h / 110 °C / Inert atmosphere 4.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C View Scheme

1: copper(l) iodide; potassium carbonate; N-methyl-2-(methylamino)ethylamine / toluene / 24 h / 110 °C / Inert atmosphere 2: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C View Scheme

1.1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere 1.2: 0 °C / Inert atmosphere 2.1: copper(l) iodide; potassium carbonate; N-methyl-2-(methylamino)ethylamine / toluene / 24 h / 110 °C / Inert atmosphere 3.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C View Scheme

1: acetic acid; hydrogen bromide / water / 12 h / 100 °C 2: Na2S2O5; ammonium hydroxide / water / 96 h / 100 °C View Scheme

carbon disulfide; aluminium trichloride Erhitzen des Reaktionsprodukts mit wss. Salzsaeure;

dihydrogen peroxide T=25°C; pH=7.1; aq. buffer; Kinetics;