反应条件
N,N-dimethyl-aniline in tetrahydrofuran Ar; Bu3SnLi THF cooled to -40 °C; substrate added (30 s) in THF; stirred (15 min); poured in NH4Cl-soln. and petroleum ether; org. layer washed (brine), dried (Na2SO4); filtered; concd.; CH2Cl2 added; addn. ClCH2OCH3, aniline (16h, room temp.); poured into petroleum ether; washed (0.5 N HCl, water, Na2CO3-soln.); drying of org. layer (Na2SO4); filtered; concd.; chromd. (silica gel; ethyl acetate/petroleum ether 0.5:99.5);;
参考文献
Sawyer,J.S.; Kucerovy,A.; Macdonald,T.L.
Journal of the American Chemical Society, 1988 , vol. 110, p. 842
