2,2,2-三氟乙醇合成路线 （共 1089 条）
参考文献
Schmidt-Leithoff, Joachim; Brueckner, Reinhard
Synlett, 2006 , # 16 p. 2641 - 2645
反应条件
triethylamine
T=65°C;
参考文献
Hanack,M.; Auchter,G.
Journal of the American Chemical Society, 1985 , vol. 107, p. 5238
参考文献
Hanack,M. et al.
Journal of the American Chemical Society, 1979 , vol. 101, p. 100 - 108
反应条件
in water
T=70°C; var. of solvent, ΔH(excit.); KineticsProduct distributionThermodynamic data;
参考文献
Auchter, Gerhard; Hanack, Michael
Chemische Berichte, 1982 , vol. 115, # 10 p. 3402 - 3413
反应条件
triethylamine
T=65°C;
参考文献
Hanack,M.; Auchter,G.
Journal of the American Chemical Society, 1985 , vol. 107, p. 5238
参考文献
Hanack,M. et al.
Journal of the American Chemical Society, 1979 , vol. 101, p. 100 - 108
参考文献
Dietliker,K. et al.
Helvetica Chimica Acta, 1976 , vol. 59, p. 2074 - 2099
反应条件
1: 2,2,2-trifluoroethanol With sodium hydride in tetrahydrofuran
T=0 - 20°C; 1 h;
2: 4-fluoro-nitro-benzene in tetrahydrofuran
T=20°C; 3 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1810677 A1, 2007 ;
Location in patent: Page/Page column 61 ;
EP 1810677 A1
反应条件
sodium hydride in N,N-dimethyl-formamide
1.) r.t., 2.) 130 deg C, 10 h;
参考文献
Preschera, Dietrich; Thiele, Thomas; Ruhmann, Ralf
Journal of Fluorine Chemistry, 1996 , vol. 79, # 2 p. 145 - 148
反应条件
tetrabutyl ammonium fluoride in N,N-dimethyl-formamide
T=20°C; 1 h;
参考文献
Tejero, Ismael; Huertas, Imma; Gonzalez-Lafont, Angels; Lluch, Jose M.; Marquet, Jordi
Journal of Organic Chemistry, 2005 , vol. 70, # 5 p. 1718 - 1727
