4’-溴-2-羟基苯乙酮乙酸酯合成路线 （共 28 条）
反应条件
[bmim]Br
T=20°C; 0.5 h;
参考文献
Kamal, Ahmed; Chouhan, Gagan
Tetrahedron Letters, 2004 , vol. 45, # 48 p. 8801 - 8805
反应条件
acetic acid in ethanol; water
T=2.5°C; Heating;
参考文献
Kaila, Neelu; Janz, Kristin; DeBernardo, Silvano; Bedard, Patricia W.; Camphausen, Raymond T.; Tam, Steve; Tsao, Desiree H.H.; Keith Jr., James C.; Nickerson-Nutter, Cheryl; Shilling, Adam; Young-Sciame, Ruth; Wang, Qin
Journal of Medicinal Chemistry, 2007 , vol. 50, # 1 p. 21 - 39
反应条件
anhydrous iron chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; acetylacetone in N,N-dimethyl-formamide
T=125°C; 4 h;
参考文献
Zhao, Ming; Kuang, Chun Xiang; Cheng, Xue Zhi; Yang, Qing
Chinese Chemical Letters, 2011 , vol. 22, # 5 p. 571 - 574
反应条件
N-benzyl-N,N,N-triethylammonium chloride in acetonitrile
1 h; Heating;
参考文献
Vijayaraghavan, S. T.; Balasubramanian, T. R.
Journal of Organometallic Chemistry, 1985 , vol. 282, p. 17 - 22
反应条件
sodium acetate in acetic acid
5 h; Reflux;
参考文献
Perez, Daniel I.; Palomo, Valle; Perez, Concepcion; Gil, Carmen; Dans, Pablo D.; Luque, F. Javier; Conde, Santiago; Martinez, Ana
Journal of Medicinal Chemistry, 2011 , vol. 54, # 12 p. 4042 - 4056
反应条件
1: diethyl ether
View Scheme
参考文献
Tsuno et al.
Bulletin of the Chemical Society of Japan, 1959 , vol. 32, p. 960,961
Show Details
Lane; Feller
Journal of the American Chemical Society, 1951 , vol. 73, p. 4230,4231
反应条件
1,4-dioxane; copper dichloride
参考文献
Erickson et al.
Journal of the American Chemical Society, 1951 , vol. 73, p. 5301
反应条件
in chloroform
3 h; Ambient temperature;
参考文献
Ferraboschi, Patrizia; Grisenti, Paride; Manzocchi, Ada; Santaniello, Enzo
Tetrahedron, 1994 , vol. 50, # 35 p. 10539 - 10548
反应条件
1: AlCl3 / CH2Cl2
2: acetonitrile / 3 h / Heating
View Scheme
参考文献
Kamal, Ahmed; Sandbhor, Mahendra; Ahmed, Kaleem; Adil; Shaik, Ahmad Ali
Tetrahedron Asymmetry, 2003 , vol. 14, # 24 p. 3861 - 3866
反应条件
(i) SOCl2, Py, CH2Cl2, (ii) RuO2, aq. NaIO4, HIO4, tBuOH, (iii) /BRN= 607604/, 18-crown-6, MeCN; Multistep reaction;
参考文献
Cane,D.E.; Shiao,M.-S.
Journal of the American Chemical Society, 1978 , vol. 100, p. 3203 - 3207
