5-(4-甲氧基苯基)戊酸合成路线 （共 23 条）
反应条件
1: LiAlH4 2: triphenylphosphine, carbon tetrabromide View Scheme
参考文献
van der Zanden
Recueil des Travaux Chimiques des Pays-Bas, 1941 , vol. 60, p. 291,295
反应条件
sodium dichromate; sulfuric acid; acetic acid
参考文献
van der Zanden
Recueil des Travaux Chimiques des Pays-Bas, 1938 , vol. 57, p. 233,243
参考文献
van der Zanden
Recueil des Travaux Chimiques des Pays-Bas, 1938 , vol. 57, p. 233,243
反应条件
hydrogen; acetic acid; palladium 10 on activated carbon in ethanol
T=20°C;
参考文献
Japan Science and Technology Agency; Kyoto University; Nagoya City University; Pharma Frontier Co., Ltd.
Patent: EP2151236 A1, 2010 ;
Location in patent: Page/Page column 34 ;
EP 2151236 A1
反应条件
1: 50 percent / AlCl3 / 3 h / 0 °C
2: 95 percent / H2; acetic acid / Pd/C / ethanol / 4 h
View Scheme
参考文献
McCalmont, William F.; Patterson, Jaclyn R.; Lindenmuth, Michael A.; Heady, Tiffany N.; Haverstick, Doris M.; Gray, Lloyd S.; Macdonald, Timothy L.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 11 p. 3821 - 3839
反应条件
1: 50 percent / AlCl3 / 3 h / 0 °C
2: 95 percent / H2; acetic acid / Pd/C / ethanol / 4 h
View Scheme
参考文献
McCalmont, William F.; Patterson, Jaclyn R.; Lindenmuth, Michael A.; Heady, Tiffany N.; Haverstick, Doris M.; Gray, Lloyd S.; Macdonald, Timothy L.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 11 p. 3821 - 3839
反应条件
1: aluminium chloride; 1.1.2.2-tetrachloro-ethane / Behandeln des Reaktionsprodukts mit aethanol. Natronlauge
2: ethanol; amalgamated zinc; aqueous hydrochloric acid
View Scheme
参考文献
Papa; Schwenk; Hankin
Journal of the American Chemical Society, 1947 , vol. 69, p. 3018,3021
反应条件
1: lithium hydroxide hydrate / tetrahydrofuran / 24 h / |Molecular sieve; |Inert atmosphere; |Reflux
2: palladium 10 on activated carbon; hydrogen / ethanol / 12 h
3: sodium hydroxide / ethanol / 12 h / 20 °C
View Scheme
参考文献
Magrioti, Victoria; Nikolaou, Aikaterini; Smyrniotou, Annetta; Shah, Ishita; Constantinou-Kokotou, Violetta; Dennis, Edward A.; Kokotos, George
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 18 p. 5823 - 5829
反应条件
1: palladium 10 on activated carbon; hydrogen / ethanol / 12 h
2: sodium hydroxide / ethanol / 12 h / 20 °C
View Scheme
参考文献
Magrioti, Victoria; Nikolaou, Aikaterini; Smyrniotou, Annetta; Shah, Ishita; Constantinou-Kokotou, Violetta; Dennis, Edward A.; Kokotos, George
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 18 p. 5823 - 5829
反应条件
1: pyridinium chlorochromate / dichloromethane
2: sodium hydride / tetrahydrofuran
3: hydrogen; palladium on activated charcoal / ethyl acetate
4: lithium aluminium tetrahydride / tetrahydrofuran
5: pyridinium chlorochromate / dichloromethane
6: sodium hydride / tetrahydrofuran
7: hydrogen; palladium on activated charcoal / ethyl acetate
8: sodium hydroxide / ethanol
View Scheme
参考文献
Mimori, Seisuke; Okuma, Yasunobu; Kaneko, Masayuki; Kawada, Koichi; Nomura, Yasuyuki; Murakami, Yasuoki; Hamana, Hiroshi
Chemistry Letters, 2013 , vol. 42, # 9 p. 1051 - 1052
