(R)-(-)-2-甲基哌嗪合成路线

参考文献

Toda, Fumio; Tanaka, Koichi; Kido, Masaru
Chemistry Letters, 1988 , p. 513 - 516

357263-13-9BMS 378806; 1-[(2R)-4-苯甲酰基-2-甲基-1-哌嗪基]-2-(4-甲氧基-1H-吡咯并[2,3-b]吡啶-3-基)-1,2-乙二酮

参考文献

Wang, Tao; Zhang, Zhongxing; Wallace, Owen B.; Deshpande, Milind; Fang, Haiquan; Yang, Zheng; Zadjura, Lisa M.; Tweedie, Donald L.; Huang, Stella; Zhao, Fang; Ranadive, Sunanda; Robinson, Brett S.; Gong, Yi-Fei; Ricarrdi, Keith; Spicer, Timothy P.; Deminie, Carol; Rose, Ronald; Wang, Hwei-Gene Heidi; Blair, Wade S.; Shi, Pei-Yong; Lin, Pin-Fang; Colonno, Richard J.; Meanwell, Nicholas A.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 20 p. 4236 - 4239

2402-77-92,3-二氯吡啶+

75336-86-6(R)-(-)-2-甲基哌嗪

393513-95-6(3R)-1-(3-氯吡啶-2-基)-3-甲基哌嗪

参考文献

EURO-CELTQUE, S.A.
Patent: WO2004/29031 A2, 2004 ;
Location in patent: Page 174 ;
WO 2004/029031 A2

75336-86-6(R)-(-)-2-甲基哌嗪+

76-83-5三苯基氯甲烷

313657-75-91-三甲苯-(R)-3-甲基哌嗪

参考文献

BIOVITRUM AB
Patent: WO2004/829 A1, 2003 ;
Location in patent: Page 26 ;
WO 2004/000829 A1

75336-86-6(R)-(-)-2-甲基哌嗪

357262-90-94-苯甲酰基-2-甲基-1-[(7-氧化-1H-吡咯并[2,3-b]吡啶)氧代乙酰基]-哌嗪

参考文献

Wang, Tao; Zhang, Zhongxing; Wallace, Owen B.; Deshpande, Milind; Fang, Haiquan; Yang, Zheng; Zadjura, Lisa M.; Tweedie, Donald L.; Huang, Stella; Zhao, Fang; Ranadive, Sunanda; Robinson, Brett S.; Gong, Yi-Fei; Ricarrdi, Keith; Spicer, Timothy P.; Deminie, Carol; Rose, Ronald; Wang, Hwei-Gene Heidi; Blair, Wade S.; Shi, Pei-Yong; Lin, Pin-Fang; Colonno, Richard J.; Meanwell, Nicholas A.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 20 p. 4236 - 4239

75336-86-6(R)-(-)-2-甲基哌嗪+

98-88-4苯甲酰氯

357263-39-9(R)-2-甲基-4-苯甲酰基哌嗪

参考文献

AMGEN INC.
Patent: WO2009/35568 A1, 2009 ;
Location in patent: Page/Page column 69 ;
WO 2009/035568 A1

93-58-3苯酸甲酯+

75336-86-6(R)-(-)-2-甲基哌嗪

357263-39-9(R)-2-甲基-4-苯甲酰基哌嗪

参考文献

Wang, Jingsong; Le, Nhut; Heredia, Alonso; Song, Haijing; Redfield, Robert; Wang, Lai-Xi
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 9 p. 1781 - 1786

75336-86-6(R)-(-)-2-甲基哌嗪

313657-76-0(R)-2-氯-3-(2-甲基哌嗪-1-基)吡嗪

参考文献

Felicini; Fontana; Giribone; Nilsson; Oesterlund; Paptchikhine
Journal of Labelled Compounds and Radiopharmaceuticals, 2003 , vol. 46, # 1 p. 85 - 92

75336-86-6(R)-(-)-2-甲基哌嗪+

100-44-7苄基氯

132871-11-5(R)-1-苄基-3-甲基哌嗪

参考文献

F. HOFFMANN-LA ROCHE AG
Patent: WO2005/2577 A1, 2005 ;
Location in patent: Page 290-291 ;
WO 2005/002577 A1

75336-86-6(R)-(-)-2-甲基哌嗪+

100-39-0溴化苄

132871-11-5(R)-1-苄基-3-甲基哌嗪

参考文献

AMGEN INC.
Patent: WO2009/75857 A2, 2009 ;
Location in patent: Page/Page column 78-79 ;
WO 2009/075857 A2