2,3-二甲基-6-氨基喹噁啉合成路线 （共 9 条）
反应条件
5 Pd(II)/C(eggshell); hydrogen in ethanol T=20°C;
参考文献
Chen, Qianyi; Bryant, Vashti C.; Lopez, Hernando; Kelly, David L.; Luo, Xu; Natarajan, Amarnath
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 7 p. 1929 - 1932
参考文献
Allergan, Inc.
Patent: US5021416 A1, 1991 ;
反应条件
1: in tetrahydrofuran T=-78°C; 2 h; 2: With manganese(IV) oxide in chloroform 4 h; Heating; Further stages.;
参考文献
Hui, Xu; Schmidt, Fanny; Fakhfakh, Mohammed Akram; Franck, Xavier; Figadere, Bruno
Heterocycles, 2007 , vol. 72, p. 353 - 361
反应条件
1: 74 percent / Heating 2: SnCl2 / ethanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 4 p. 815 - 820
参考文献
Journal of the American Chemical Society, , vol. 70, p. 2619
反应条件
1: 78 percent / Ac2O / 1.25 h / Ambient temperature 2: 74 percent / LiAlH4 / tetrahydrofuran / 4 h / 0 - 5 °C 3: 54 percent / conc. H2SO4, KNO3 / acetic acid / 2 h / 20 °C 4: 1.) H2 / 1.) Raney nickel / 1.) EtOH, 40-45 min, 2.) 20 deg C, 3.5 h View Scheme
参考文献
Olsson, Kjell; Grivas, Spiros
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1986 , vol. 40, # 6 p. 486 - 492
反应条件
1: 78 percent / Ac2O / 1.25 h / Ambient temperature 2: 74 percent / LiAlH4 / tetrahydrofuran / 4 h / 0 - 5 °C 3: 54 percent / conc. H2SO4, KNO3 / acetic acid / 2 h / 20 °C View Scheme
参考文献
Olsson, Kjell; Grivas, Spiros
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1986 , vol. 40, # 6 p. 486 - 492
反应条件
1: 78 percent / Ac2O / 1.25 h / Ambient temperature
2: 74 percent / LiAlH4 / tetrahydrofuran / 4 h / 0 - 5 °C
View Scheme
参考文献
Olsson, Kjell; Grivas, Spiros
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1986 , vol. 40, # 6 p. 486 - 492
反应条件
potassium carbonate in acetone
7 h; Heating;
参考文献
Olsson, Kjell; Grivas, Spiros
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1986 , vol. 40, # 6 p. 486 - 492
