5-溴-1H-吡咯并[2,3-B]吡啶-3-甲醛合成路线 （共 4 条）
反应条件
1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane in water T=120°C; Sealed tube;
参考文献
The University of Tokyo; Riken; NAGANO Tetsuo; OKABE Takayoshi; KOJIMA Hirotatsu; SAITO Nae; NAKANO Hirofumi; ABE Masanao; TANAKA Akiko; HONMA Teruki; YOKOYAMA Shigeyuki; TSUGANEZAWA Keiko; YUKI Hitomi
Patent: EP2565192 A1, 2013 ;
Location in patent: Paragraph 0304 ;
反应条件
1: 5-Bromo-1H-pyrrolo[2,3-b]pyridine With AlCl3, aluminium chloride in dichloromethane 0.25 h; 2: dichloromethoxy methane in dichloromethane T=0°C; 3 h;
参考文献
US2009/253679 A1, ;
Page/Page column 40 ;
反应条件
1: With hydroxylamine hydrochloride in methanol T=20°C; 1 h; Inert atmosphere; 2: With thionyl chloride in toluene T=80 - 100°C; 24 h; 3: With sodium hydrogencarbonate in water; toluene
参考文献
Daiichi Sankyo Company, Limited
Patent: US2011/82138 A1, 2011 ;
Location in patent: Page/Page column 69 ;
US 20110082138 A1
反应条件
1: 5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde With sodium hydride in tetrahydrofuran T=0°C; 0.25 h; 2: p-toluenesulfonyl chloride in tetrahydrofuran T=0 - 20°C; 2 h;
参考文献
sanofi-aventis
Patent: US2009/253679 A1, 2009 ;
Location in patent: Page/Page column 44 ;
