1: 2-fluoro-5-bromo-pyridine With n-butyllithium; tri-isopropoxy-borane in diethyl ether T=-78 - 20°C; 2: 2,3-dimethylbutane-2,3-diol With acetic acid in diethyl ether
1: 2-Fluoro-5-iodopyridine With n-butyllithium; tri-isopropoxy-borane in diethyl ether T=-78 - 20°C; 2: 2,3-dimethylbutane-2,3-diol With acetic acid in diethyl ether
3-chloroprop-1-ene; trifluoroacetic acid; cobalt(II) dibromide in acetonitrile Zn dust (1.5 equiv., acid-activated) , CoBr2 (0.1 equiv.), stirred for 5min with allyl chloride (0.3 equiv.), a soln. of aryl halide (1 equiv.) and a soln. 1 equiv. of B compd. added at room temp., stirred for 30 mi n, tranesterificated with pinacol; hydrolized (NH4Cl), extd. (diethyl ether);
参考文献
Claudel, Stephanie; Gosmini, Corinne; Paris, Jean Marc; Perichon, Jacques
Chemical Communications, 2007 , # 35 p. 3667 - 3669
