反应条件
1: triethylamine / CH2Cl2 / 24 h / 20 - 25 °C
2: 1.) CuI / 1.) THF, -30 deg C, 15 min, 2.) THF, -30 deg C, 1 h
3: 1.) potassium tert-butoxide / 1.) THF, 45 deg C, 45 min; other reagents: NaH, NaOH/tetrabutylammonium bromide, NaOH/tetrabutylammonium fluoride, 2.) THF, 21 deg C, 1 h
4: 1.) ozone, Sudan red, 2.) NaBH4, NaOH / 1.) CH2Cl2, ethanol, 2.) CH2Cl2, ethanol, 25 deg C, 12-16 h
5: 88 percent / triethylamine / CH2Cl2 / 0 - 5 °C / 1-2 h
View Scheme
参考文献
Faul, Margaret M.; Winneroski, Leonard L.; Krumrich, Christine A.; Sullivan, Kevin A.; Gillig, James R.; Neel, David A.; Rito, Christopher J.; Jirousek, Michael R.
Journal of Organic Chemistry, 1998 , vol. 63, # 6 p. 1961 - 1973
