3-甲基-3-丁烯-1-醇合成路线 （共 220 条）
反应条件
1: 2-methyl-4-hydroxy-1-butene With sodium hydride in tetrahydrofuran; mineral oil
0.25 h; Cooling with ice;
2: monobromoacetic acid in tetrahydrofuran; mineral oil
2 h; Reflux;
参考文献
Cheng, Yi An; Chen, Tao; Tan, Chong Kiat; Heng, Jun Jie; Yeung, Ying-Yeung
Journal of the American Chemical Society, 2012 , vol. 134, # 40 p. 16492 - 16495,4
反应条件
sodium hydroxide; borane; dihydrogen peroxide; sodium hydride
Multistep reaction;
参考文献
VanMiddlesworth, Frank; Wang, Yi Fong; Zhou, Bing-nan; DiTullio, Dennis; Sih, C. J.
Tetrahedron Letters, 1985 , vol. 26, # 8 p. 961 - 964
参考文献
Furman, Bartlomiej; Dziedzic, Magdalena
Tetrahedron Letters, 2003 , vol. 44, # 45 p. 8249 - 8252
反应条件
1: With TBAH2PO4; trichloroacetonitrile in acetonitrile
T=20°C; 2 h;
2: With ammonium hydroxide in water
pH=8;
参考文献
Lira, Lucas M.; Vasilev, Dimitar; Pilli, Ronaldo A.; Wessjohann, Ludger A.
Tetrahedron Letters, 2013 , vol. 54, # 13 p. 1690 - 1692
反应条件
1H-imidazole; iodine; triphenylphosphine in dichloromethane
T=20°C; 4 h;
参考文献
Helmboldt, Hannes; Koehler, Daniel; Hiersemann, Martin
Organic Letters, 2006 , vol. 8, # 8 p. 1573 - 1576
反应条件
Montmorillonite K10
T=20°C; 216 h;
参考文献
Desaubry, Laurent; Nakatani, Yoichi; Ourisson, Guy
Tetrahedron Letters, 2003 , vol. 44, # 36 p. 6959 - 6961
反应条件
1: montmorillonite K 10 / 216 h / 20 °C
2: montmorillonite K10 / 216 h / 20 °C
View Scheme
参考文献
Desaubry, Laurent; Nakatani, Yoichi; Ourisson, Guy
Tetrahedron Letters, 2003 , vol. 44, # 36 p. 6959 - 6961
反应条件
hydrogenchloride; n-butyllithium; N,N,N',N,-tetramethylethylenediamine
1.) hexane, HMPA, -23 deg C, 30 min; room temperature, 8 h; Yield given. Multistep reaction;
参考文献
Poppe, Laszlo; Novak, Lajos; Szantay, Csaba
Synthetic Communications, 1987 , vol. 17, # 2 p. 173 - 180
反应条件
n-butyllithium; N,N,N',N,-tetramethylethylenediamine
1) hexane, 25 deg C, 12 h; 2) THF, hexane, -70 deg C, 1 h, -70 - 25 deg C, 20 min; Yield given. Multistep reaction;
参考文献
Moiseenkov, A. M.; Lozanova, A. V.; Surkova, A. A.; Dragan, V. A.; Strelenko, Yu. A.; Buevich, A. V.
Russian Chemical Bulletin, 1994 , vol. 43, # 1 p. 153 - 160
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1994 , # 1 p. 156 - 163
反应条件
Hg(OTf)2 in nitromethane
T=-20°C; 1 h; Yield givenFurther byproducts given;
参考文献
Nishizawa; Shigaraki; Takao; Imagawa; Sugihara
Tetrahedron Letters, 1999 , vol. 40, # 6 p. 1153 - 1156
